Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects.

Li N; Hao M; Phalen RF; Hinds WC; Nel AE

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Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects.

机译：空气污染物和哮喘。氧化应激在PM引起的不良健康影响中的作用范式。

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Asthma is a chronic inflammatory disease, which involves a variety of different mediators, including reactive oxygen species. There is growing awareness that particulate pollutants act as adjuvants during allergic sensitization and can also induce acute asthma exacerbations. In this communication we review the role of oxidative stress in asthma, with an emphasis on the pro-oxidative effects of diesel exhaust particles and their chemicals in the respiratory tract. We review the biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma.

机译：哮喘是一种慢性炎症性疾病，涉及多种不同的介质，包括活性氧。人们越来越意识到，颗粒污染物在变态反应致敏过程中充当佐剂，并且还可以诱发急性哮喘发作。在本交流中，我们回顾了氧化应激在哮喘中的作用，重点是柴油机废气颗粒及其化学物质在呼吸道中的促氧化作用。我们审查了氧化应激的生物学，包括保护性和伤害性效应，这些效应解释了颗粒物诱导的氧化应激对哮喘的影响。

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2003年第3期|共16页
作者
Li N; Hao M; Phalen RF; Hinds WC; Nel AE;
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正文语种 eng
中图分类临床医学;
关键词
Asthma; Oxidative Stress; Role; paradigm; Particulate; 哮喘; 氧化性应激; 角色;

机译：Asthma;Oxidative Stress;Role;paradigm;Particulate;哮喘;氧化性应激;角色;

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1. Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. [J] . Li N, Hao M, Phalen RF, Clinical immunology: The official journal of the Clinical Immunology Society . 2003,第3期

机译：空气污染物和哮喘。氧化应激在PM引起的不良健康影响中的作用范式。
2. Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma. [J] . Li N, Nel AE Antioxidants and redox signalling . 2006,第1a2期

机译：Nrf2介导的信号通路作为炎症的负调节剂的作用：对微粒污染物对哮喘的影响的意义。
3. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. [J] . Nel AE, Diaz-Sanchez D, Li N Current opinion in pulmonary medicine . 2001,第1期

机译：微粒污染物在肺部炎症和哮喘中的作用：有机化学物质和氧化应激的证据。
4. The Influence of Adjustments for Longterm Trends in Air Pollutant Levels on Analyses of Air Pollutant Exposures and Adverse Birth Outcomes [C] . Air Waste Management Association's annual conference exhibition . 2009

机译：对空气污染水平的长期趋势调整对空气污染物暴露和不良出生成果的影响
5. Examination of the adverse effects of gaseous and particulate oxidant air pollutants in human airway epithelial cells. [D] . Gibbs-Flournoy, Eugene A., II. 2013

机译：检查气态和颗粒性氧化剂空气污染物对人气道上皮细胞的不利影响。
6. Oxidative stress: its role in air pollution and adverse health effects [O] . F. Kelly 2003

机译：氧化应激：其在空气污染和不良健康影响中的作用
7. Oxidative stress: Its role in air pollution and adverse health effects [O] . Kelly, F J 2003

机译：氧化应激：其在空气污染和不良健康影响中的作用
8. Draft Regulatory Impact Analysis and Oxides of Nitrogen Pollutant Specific Study. Control of Air Pollution from New Motor Vehicles and New Motor Vehicle Engines: Gaseous Emission Regulations for 1987 and Later Model Year Light-Duty Vehicles, Light-Duty Trucks, and Heavy-Duty Engines; Particulate Emission Regulations for 1987 and Later Model Year Heavy-Duty Diesel Engines [R] . 1987

机译：法规影响分析和氮污染物特定研究的氧化物草案。控制新机动车和新机动车发动机的空气污染：1987年及以后的轻型车辆，轻型卡车和重型发动机的气体排放法规; 1987年及以后的模型年重型柴油机的微粒排放法规

Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects.

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