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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Early hyperbaric oxygen therapy attenuates disease severity in lupus-prone autoimmune (NZB x NZW) F1 mice.
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Early hyperbaric oxygen therapy attenuates disease severity in lupus-prone autoimmune (NZB x NZW) F1 mice.

机译：早期高压氧疗法可减轻易患狼疮的自身免疫（NZB x NZW）F1小鼠的疾病严重程度。

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摘要

The effects of hyperbaric oxygen (HBO(2)) therapy on the immune system are reported including potential changes to the CD4/CD8 ratio and a decreased proliferation of lymphocytes during exposure. The immunosuppressive effect of HBO(2) had been suggested to be applicable for the treatment of certain autoimmune diseases. (NZB x NZW) F1 hybrid mice, the unique lupus-prone mice, have been used for elucidating the pathogenesis of SLE. To investigate the effect of HBO(2) on NZB/W F1 lupus-prone mice, 32 female mice were divided into four groups. Three groups of mice were treated with HBO(2) (2.5 atm abs (ATA) for 90 min daily over 2 weeks) starting at (A) 3 months, (B) 6 months, or (C) 8 months of age, while the remaining group (D) served as control. Animals were followed until 11 months of age. Experimental parameters included life span, proteinuria, peripheral lymphocytes, anti-dsDNA antibody titers, and renal histopathology. HBO(2) treatment resulted in increased survival, decreased proteinuria, alterations in lymphocyte-subset redistribution, reduced anti-dsDNA antibody titers, and amelioration of immune-complex deposition in groups A and B. Our data demonstrated that HBO(2) therapy attenuated disease severity in NZB/W F1 mice. HBO(2) treatment may be of use in the clinical treatment of lupus patients and would benefit from further study.
机译：据报道高压氧（HBO（2））治疗对免疫系统的影响包括暴露期间CD4 / CD8比值可能发生变化以及淋巴细胞增殖减少。有人建议HBO（2）的免疫抑制作用可用于某些自身免疫性疾病的治疗。 （NZB x NZW）F1杂交小鼠，独特的易患狼疮的小鼠，已被用于阐明SLE的发病机理。为了研究HBO（2）对NZB / W F1狼疮易感小鼠的影响，将32只雌性小鼠分为四组。从（A）3个月，（B）6个月或（C）8个月大时开始，三组小鼠接受HBO（2）（2.5 atm abs（ATA）在2周内每天治疗90分钟），而其余的组（D）用作对照。跟踪动物直到11个月大。实验参数包括寿命，蛋白尿，外周淋巴细胞，抗dsDNA抗体滴度和肾脏组织病理学。 HBO（2）治疗导致存活率提高，蛋白尿减少，淋巴细胞亚群重新分布改变，抗dsDNA抗体滴度降低以及A和B组免疫复合物沉积的改善。我们的数据表明HBO（2）治疗减弱NZB / W F1小鼠的疾病严重程度。 HBO（2）治疗可能在狼疮患者的临床治疗中有用，并将受益于进一步的研究。

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