• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients.
【24h】

Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients.

机译：恢复的SARS患者对严重急性呼吸综合征冠状病毒（SARS-CoV）S抗原的长效效应子/中央记忆T细胞应答。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The role of cell-mediated immunity in human SARS-CoV infection is still not well understood. In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-gamma using ELISA and ELISpot assays. Flow cytometric analysis showed that both CD4(+) and CD8(+) T cells were involved in cellular responses against SARS-CoV infection. Interestingly, most of SARS-CoV S-specific memory CD4(+) T cells were central memory cells expressing CD45RO(+) CCR7(+) CD62L(-). However, the majority of memory CD8(+) T cells revealed effector memory phenotype expressing CD45RO(-) CCR7(-) CD62L(-). Thus, our study provides the evidence that SARS-CoV infection in humans can induce cellular immune response that is persistent for a long period of time. These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.
机译：细胞介导的免疫在人类SARS-CoV感染中的作用仍不清楚。在这项研究中，我们发现通过使用ELISA和ELISpot分析检测IFN-γ的产生，SARS-CoV感染后，记忆性T细胞对棘突（S）蛋白的反应持续了1年以上。流式细胞仪分析表明，CD4（+）和CD8（+）T细胞均参与针对SARS-CoV感染的细胞应答。有趣的是，大多数SARS-CoV S特异性记忆CD4（+）T细胞是表达CD45RO（+）CCR7（+）CD62L（-）的中央记忆细胞。但是，大多数记忆CD8（+）T细胞揭示了表达CD45RO（-）CCR7（-）CD62L（-）的效应器记忆表型。因此，我们的研究提供了证据，证明人类SARS-CoV感染可以诱导持续很长时间的细胞免疫反应。这些数据可能对设计针对SARS-CoV感染的有效疫苗的可能性具有重要意义，特别是在定义与保护性免疫有关的T细胞群体方面。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号