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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction.
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The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction.

机译：环丙沙星在人混合淋巴细胞反应过程中的免疫抑制作用。

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摘要

Interleukin (IL)-18, which is elevated in the plasma during acute rejection after organ transplantation, is known to induce the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40 and CD40 ligand (CD40L) on monocytes, the production of interferon (IFN)-gamma and IL-12 and the proliferation of lymphocytes during the human mixed lymphocyte reaction (MLR). Ciprofloxacin (CIP), which is useful for the clinical treatment of infections due to its antibacterial properties after transplantation, was shown to suppress the IFN-gamma and IL-12 production, the lymphocyte proliferation and the ICAM-1, B7.1, B7.2 and CD40 expression on monocytes during MLR in the presence of IL-18. CIP also induced the production of prostaglandin (PG) E2. In order to determine whether the effects of CIP on the expression of the activation markers were due to CIP-dependent production of PGE2, we examined the effect of cyclooxygenase (COX)-2 and protein kinase A (PKA) inhibitors on the actions of CIP. Thereby, theinhibitors were found to abolish the actions of CIP. These results therefore suggest that CIP might exert its immune modulatory effects via the production of PGE2.
机译：器官移植后急性排斥反应期间血浆中的白介素（IL）-18升高，可诱导细胞间粘附分子（ICAM）-1，B7.1，B7.2，CD40和CD40配体（CD40L ）在人类混合淋巴细胞反应（MLR）期间，单核细胞上的干扰素（IFN）-γ和IL-12的产生以及淋巴细胞的增殖。环丙沙星（CIP）由于具有移植后的抗菌特性，可用于临床治疗感染，已显示出抑制IFN-γ和IL-12产生，淋巴细胞增殖以及ICAM-1，B7.1，B7的作用.2和IL-40存在下MLR期间单核细胞上CD40的表达。 CIP还诱导了前列腺素（PG）E2的产生。为了确定CIP对激活标记物表达的影响是否归因于CIP依赖的PGE2产生，我们检查了环氧合酶（COX）-2和蛋白激酶A（PKA）抑制剂对CIP作用的影响。因此，发现抑制剂消除了CIP的作用。因此，这些结果表明，CIP可能通过产生PGE2发挥其免疫调节作用。

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