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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liver.
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Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liver.

机译：慢性乙醇消耗对肝脏中补体成分和急性期蛋白表达的影响。

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The complement system can provoke but also participate in the repair of liver injury. Here we investigated by microarray analysis the effect of chronic ethanol consumption on hepatic mRNA expression of complement components and acute-phase proteins in complement C3-deficient (C3(-/-)) and wild-type (C3(+/+)) mice. Up-regulation by ethanol of factor B, C1qA-chain and clusterin but down-regulation of factor H, Masp-2, factor D and the terminal components C6, C8alpha and C9 was seen in both strains. Ethanol up-regulated C2 and down-regulated C4bp only in C3(+/+) mice, while in C3(-/-) mice up-regulation of C1qB-chain and vitronectin was observed. The expression of factor B, C6, C1qB and factor I was lower but that of factor D higher in C3(-/-) than in C3(+/+) mice. Ethanol induced mRNA synthesis of many acute-phase proteins including SPARC and lipocalin-2, but reduced the expression of SAP. The induction of early classical and alternative pathway components and suppression of terminal pathway components and soluble regulators may thus contribute to alcohol-induced liver injury. Lipocalin-2 and SPARC emerge as new candidate markers for early detection of liver damage.
机译：补体系统可引起但也参与肝损伤的修复。在这里，我们通过微阵列分析调查了慢性乙醇消耗对补体C3缺陷（C3（-/-））和野生型（C3（+ / +））小鼠补体成分和急性期蛋白肝mRNA表达的影响。在两个菌株中，乙醇均上调了因子B，C1qA链和簇蛋白的表达，但下调了因子H，Masp-2，因子D和末端成分C6，C8alpha和C9的表达。乙醇仅在C3（+ / +）小鼠中上调C2和下调C4bp，而在C3（-/-）小鼠中观察到C1qB链和玻连蛋白上调。与C3（+ / +）小鼠相比，C3（-/-）中B，C6，C1qB和I因子的表达较低，而D因子较高。乙醇诱导许多急性期蛋白（包括SPARC和lipocalin-2）的mRNA合成，但降低了SAP的表达。因此，早期经典途径和替代途径成分的诱导以及终端途径成分和可溶性调节剂的抑制可能有助于酒精引起的肝损伤。 Lipocalin-2和SPARC成为早期检测肝损伤的新候选标记。

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