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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Serum surfactant protein D is correlated to development of dementia and augmented mortality.
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Serum surfactant protein D is correlated to development of dementia and augmented mortality.

机译：血清表面活性剂蛋白D与痴呆的发展和死亡率的增加有关。

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Development of dementia, including Alzheimer's disease (AD), is associated with lipid dysregulation and inflammation. As the host defense lectin surfactant protein D (SP-D) has multiple effects in lipid homeostasis and inflammation, the correlation between SP-D concentrations and development of dementia was investigated. A total of 418 non-demented persons were included in the study and cognitively re-examined after 3 years, while survival was followed for 11 years. Serum SP-D concentrations were measured at baseline. Logistic regression analysis controlling for age, gender, smoking status, and CRP showed that Odds Ratio for developing dementia was 2.62 (1.12-6.15) with an SP-D concentration in the highest quartile compared to the other quartiles. The risk of AD was 2.55 (0.95-6.90). Cox regression controlling for the same variables showed that hazard ratio of death was 1.43 (1.06-1.92) in the highest quartile. SP-D concentration thus correlates to development of dementia as well as to augmented mortality.
机译：包括阿尔茨海默氏病（AD）在内的痴呆症的发展与脂质失调和炎症有关。由于宿主防御素凝集素表面活性剂蛋白D（SP-D）在脂质稳态和炎症中具有多种作用，因此研究了SP-D浓度与痴呆症发展之间的相关性。总共418名非痴呆症患者被纳入研究，并在3年​​后进行了认知再检查，生存期为11年。在基线时测量血清SP-D浓度。对年龄，性别，吸烟状况和CRP进行的Logistic回归分析显示，与其他四分位数相比，发展中的痴呆的几率为2.62（1.12-6.15），其中SP-D浓度最高。 AD的风险是2.55（0.95-6.90）。 Cox回归控制相同的变量表明，最高四分位数中的死亡危险比为1.43（1.06-1.92）。因此，SP-D的浓度与痴呆的发展以及死亡率的增加有关。

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