• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Altered susceptibility to EAE in congenic NOD mice: Altered processing of the encephalitogenic MOG35-55 peptide by NOR/LtJ mice.
【24h】

Altered susceptibility to EAE in congenic NOD mice: Altered processing of the encephalitogenic MOG35-55 peptide by NOR/LtJ mice.

机译：在同类NOD小鼠中对EAE的敏感性发生了变化：NOR / LtJ小鼠对致脑炎性MOG35-55肽的加工发生了变化。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

NOD mice (H-2 g7) naturally develop autoimmune diabetes, while the congenic NOR/LtJ mice (H-2 g7) are resistant. To determine if defective immune regulation renders NOD susceptible to autoimmune disease, we compared MOG35-55-induced EAE in NOD mice to that of NOR/LtJ. In two of three immunization protocols, the NOR/LtJ mice developed significantly reduced indices and severity of clinical disease, in spite of an exaggerated autoimmune response to MOG35-55. Characterization of the responding T cell repertoires revealed that V beta 8+ Th cells directed toward the MOG42-55 core epitope were dominant in both strains. Interestingly, CD8+ CTL were absent or significantly reduced in MOG35-55 lymphoblasts from NOR/LtJ mice, which poorly processed the MOG39-47 CTL epitope from MOG35-55. Thus, while particular MHC class II alleles may be associated with increased risk, molecules involved in the processing of key epitopes may be influential in the progression of autoimmune disease.
机译：NOD小鼠（H-2 g7）自然发展为自身免疫性糖尿病，而同基因NOR / LtJ小鼠（H-2 g7）具有抗药性。为了确定是否有缺陷的免疫调节使NOD易患自身免疫性疾病，我们将MOG35-55诱导的NOD小鼠中的EAE与NOR / LtJ进行了比较。在三种免疫方案中的两种中，尽管对MOG35-55的自身免疫反应过度，但NOR / LtJ小鼠的临床疾病指标和严重程度却大大降低。响应的T细胞库的表征表明，针对MOG42-55核心表位的V beta 8+ Th细胞在这两种菌株中均占优势。有趣的是，NOR / LtJ小鼠的MOG35-55淋巴母细胞中CD8 + CTL缺失或显着减少，而MOG35-55的MOG39-47 CTL表位加工较差。因此，尽管特定的II类MHC等位基因可能与增加的风险相关，但参与关键表位加工的分子可能对自身免疫疾病的进展有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号