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首页> 外文期刊>Journal of psychiatric research >The association between course of illness and subsequent morbidity in bipolar I disorder.
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The association between course of illness and subsequent morbidity in bipolar I disorder.

机译：躁郁症I病的病程与随后发病率之间的关联。

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OBJECTIVE: We examined the relationship between certain bipolar I disorder clinical course variables over 5 years with outcome over the subsequent 5-year period. METHODS: Prospective observational follow-up data of 123 bipolar I subjects were analyzed. Predictive clinical variables included the frequency and direction of switches, and the quantity, polarity and length of affective periods. Outcome variables were an affective burden index (ABI) accounting for week-by-week severity and weeks hospitalized. Bivariate analyses guided the selection of predictors for multivariable analyses against the outcome variables. RESULTS: Affective burden index: while the number and direction of switches, the number of polyphasic episodes, weeks in hypomania/mania/mixed state, weeks in minor/major depression, weeks in at least marked affective syndrome, and weeks in any affective syndrome all had bivariate correlation (p<0.01) with the ABI, only weeks in hypomania/mania/mixed state and weeks in minor/major depression made significant contributions in the multivariable analysis (p<0.01) with the ABI. Weeks hospitalized: weeks in at least marked affective syndrome were significantly correlated with weeks hospitalized in bivariate analysis (p<0.01), and maintained a contribution to weeks hospitalized in the multivariable analysis (p<0.01). CONCLUSIONS: The quantity and severity of weeks in symptomatic affective states are possibly greater predictors of affective burden in bipolar I patients than the quantity and direction of affective switches.
机译：目的：我们研究了5年来某些双相I型障碍的临床病程变量与随后5年的结果之间的关系。方法：对123名双相I受试者的前瞻性观察随访数据进行了分析。可预测的临床变量包括开关的频率和方向，以及情感期的数量，极性和长度。结果变量是一个情感负担指数（ABI），说明每周的严重程度和住院的几周。双变量分析指导针对结果变量进行多变量分析的预测因子的选择。结果：情感负担指数：开关的数量和方向，多相发作的数量，躁狂症/躁狂症/混合状态的几周，轻度/重度抑郁症的几周，至少明显的情感综合征的几周以及任何情感综合征的几周所有患者与ABI均具有二元相关性（p <0.01），仅在躁狂/躁狂/混合状态下数周和轻度/重度抑郁状态下数周对ABI进行多变量分析（p <0.01）。住院周数：至少有明显情感综合症的周数与双变量分析的住院周数显着相关（p <0.01），并在多变量分析中维持住院周数的贡献（p <0.01）。结论：症状性情感状态下几周的数量和严重程度可能比情感转换的数量和方向更能预测双相I患者的情感负担。

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