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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Secretory immunoglobulin A (sIgA) deficiency in serum of patients with GALTectomy (appendectomy and tonsillectomy).
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Secretory immunoglobulin A (sIgA) deficiency in serum of patients with GALTectomy (appendectomy and tonsillectomy).

机译：GALT切除术（阑尾切除术和扁桃体切除术）患者血清中分泌型免疫球蛋白A（sIgA）缺乏。

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INTRODUCTION: In adult human beings, 80-85% of the immune cells are located in the digestive tract mucosa; hence the importance of the Gut Associated Lymphoid Tissue (GALT) in host defence. We studied the influence of the surgical removal of two important parts of the gut associated with lymphoid tissue (tonsillectomy and appendectomy) on immune parameters. METHODS: One hundred and sixty patients were enrolled in this study. They were divided into four groups of forty patients each and matched for gender and age: group 1, appendectomized and tonsillectomized; group 2, only appendectomized; group 3, only tonsillectomized; and group 4, control group, neither tonsillectomized nor appendectomized. We analysed in blood: hemogram, protein electrophoresis, lymphocytic populations (T4 cells, T8 cells, NK cells), IgG, IgM, IgA immunoglobulin, and their fractions IgA1, IgA2, and secretory IgA. RESULTS: Levels of secretory IgA in serum of patients in group 1 were significantly lower than in the other three groups(1.89 mg/dl, group 1; 2.32 mg/dl, group 2; 2.19 mg/dl, group 3 and 4.97 mg/dl, group 4; p<0.0001). Also, the values found in the two groups that had undergone only one of the operations were clearly lower than in control patients (p<0.0001). In this study, the reduction was sustained for a period of between 3 months and 3 years in appendectomized patients, and more than 20 years in tonsillectomized patients. IN SUMMARY: GALTectomy (appendectomy and tonsillectomy) significantly decreases secretory IgA levels in serum. The decrease is more intense when both operations have been done.
机译：简介：在成年人类中，80-85％的免疫细胞位于消化道粘膜中。因此，肠道相关淋巴组织（GALT）在宿主防御中的重要性。我们研究了手术切除与淋巴样组织相关的肠道的两个重要部分（扁桃体切除术和阑尾切除术）对免疫参数的影响。方法：160名患者参加了这项研究。将他们分为四组，每组四十名患者，并按性别和年龄进行匹配：第1组，接受了切除和扁桃体切除;第2组，仅切除肠壁;第三组，仅扁桃体切除;第4组，对照组，既未行扁桃体切除术也未行阑尾切除术。我们在血液中进行了分析：血象图，蛋白质电泳，淋巴细胞群体（T4细胞，T8细胞，NK细胞），IgG，IgM，IgA免疫球蛋白及其组分IgA1，IgA2和分泌型IgA。结果：第一组患者血清中分泌型IgA水平明显低于其他三组（1.89 mg / dl，第一组; 2.32 mg / dl，第二组; 2.19 mg / dl，第三组和4.97 mg / dl） d1，第4组; p ＜0.0001）。另外，两组仅进行了一项手术的值明显低于对照组（p <0.0001）。在这项研究中，阑尾切除术患者的减少持续了3个月至3年，扁桃体切除术患者的减少持续了20多年。总结：胃切除术（阑尾切除术和扁桃体切除术）可显着降低血清中分泌型IgA水平。两项操作都完成后，减少幅度更大。

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