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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >T cell subset-specific susceptibility to aging.
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T cell subset-specific susceptibility to aging.

机译：T细胞亚群特异性衰老敏感性。

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摘要

With increasing age, the competence of the immune system to fight infections and tumors declines. Age-dependent changes have been mostly described for human CD8 T cells, raising the question of whether the response patterns for CD4 T cells are different. Gene expression arrays of memory CD4 T cells yielded a similar age-induced fingerprint as has been described for CD8 T cells. In cross-sectional studies, the phenotypic changes were not qualitatively different for CD4 and CD8 T cells, but occurred much more frequently in CD8 T cells. Homeostatic stability partially explained this lesser age sensitivity of CD4 T cells. With aging, naive and central memory CD8 T cells were lost at the expense of phenotypically distinct CD8 effector T cells, while effector CD4 T cells did not accumulate. However, phenotypic shifts on central memory T cells were also more pronounced in CD8 T cells. This distinct stability in cell surface marker expression can be reproduced in vitro. The data show that CD8 T cells are age sensitive by at least two partially independent mechanisms: fragile homeostatic control and gene expression instability in a large set of regulatory cell surface molecules.
机译：随着年龄的增长，免疫系统抵抗感染和肿瘤的能力下降。关于人类CD8 T细胞的年龄依赖性变化已得到了大多数描述，这引发了CD4 T细胞反应模式是否不同的问题。记忆CD4 T细胞的基因表达阵列产生了与CD8 T细胞类似的年龄诱导指纹。在横断面研究中，CD4和CD8 T细胞的表型变化在质量上没有差异，但在CD8 T细胞中更频繁地发生。稳态稳定性部分解释了CD4 T细胞的这种年龄敏感性降低。随着年龄的增长，幼稚的和中央记忆的CD8 T细胞丢失，以表型上不同的CD8效应T细胞为代价，而效应CD4 T细胞没有积累。但是，中央记忆T细胞的表型转移在CD8 T细胞中也更为明显。细胞表面标志物表达的这种独特的稳定性可以在体外复制。数据表明，CD8 T细胞通过至少两个部分独立的机制对年龄敏感：脆弱的稳态控制和大量调节细胞表面分子中的基因表达不稳定性。

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