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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Association of the interleukin (IL)-16 gene polymorphisms with Graves' disease.
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Association of the interleukin (IL)-16 gene polymorphisms with Graves' disease.

机译：白介素（IL）-16基因多态性与Graves病的关联。

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摘要

Interleukin (IL)-16 was one of the cytokines with the function of T helper cell recruitment, whose expression in the thyrocyte and orbital fibroblast of Graves' disease (GD) patients was increased. Recently association of IL-16 gene polymorphisms with autoimmune diseases had been reported. However, there was little known about the impact of IL-16 gene polymorphisms on GD. In this study, we performed a case-control association study of three tagSNPs (rs4778889-rs1131445-rs4778641) within the IL-16 gene on 258 patients with GD and 208 healthy subjects in the Chinese population. Our data showed that common IL-16 variants were associated with GD (P=0.013-0.0186) and Graves' disease associated ophthalmopathy (GO) (P=0.0033-0.041). A novel protective haplotype containing the three tagSNPs (C-T-C) was observed in association with GO (P=0.013). In conclusion, IL-16 gene was significantly associated with susceptibility to Graves' disease and Graves' disease associated ophthalmopathy in the Chinese population.
机译：白介素（IL）-16是具有T辅助细胞募集功能的细胞因子之一，其在Graves病（GD）患者的甲状腺细胞和眼眶成纤维细胞中的表达增加。最近已经报道了IL-16基因多态性与自身免疫性疾病的关联。但是，关于IL-16基因多态性对GD的影响知之甚少。在这项研究中，我们对258例GD患者和208例健康人群中的IL-16基因中的三个tagSNP（rs4778889-rs1131445-rs4778641）进行了病例对照研究。我们的数据显示常见的IL-16变体与GD（P = 0.013-0.0186）和Graves病相关的眼病（GO）（P = 0.0033-0.041）相关。观察到一种新型的保护性单倍型，含有三个tagSNPs（C-T-C）与GO（P = 0.013）。总之，IL-16基因与中国人群对Graves病和Graves病相关的眼病的易感性显着相关。

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