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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Intensification of a suppressive HAART regimen increases CD4 counts and decreases CD8+ T-cell activation.
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Intensification of a suppressive HAART regimen increases CD4 counts and decreases CD8+ T-cell activation.

机译：抑制性HAART方案的强化会增加CD4计数并减少CD8 + T细胞活化。

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摘要

A significant proportion of HIV-1-infected individuals on suppressive HAART regimens do not reconstitute CD4 counts well. If viral reservoirs persist and impact on CD4 reconstitution in a percentage of cases then addition of another antiretroviral agent could further suppress these reservoirs resulting in enhanced CD4 recovery. To evaluate this possibility, we studied the effect of adding abacavir to a chronically suppressive NNRTI containing HAART regimen for 8 patients on their CD4 count and expression of activation markers. Over the first 24 weeks of intensification, CD4 counts increased significantly (p=0.028). This increase continued after a year in follow-up with a significant rate of change in CD4 T-cells of 0.959+/-1.27 per week. In addition, during intensification changes in the percentage of CD38+CD8+ T-cells over time were significantly negatively correlated with changes in CD4 cell number over time above increases predicted without intensification (r(2)=0.716, p=0.008). These data support the possibility that in certain cases where suboptimal CD4 reconstitution occurs that intensification of the regimen can impact immunologic parameters.
机译：抑制性HAART方案中有很大一部分被HIV-1感染的个体不能很好地重构CD4计数。如果病毒库持续存在并在一定百分比的情况下影响CD4重构，则添加另一种抗逆转录病毒药物可以进一步抑制这些库，从而提高CD4的回收率。为了评估这种可能性，我们研究了将阿巴卡韦添加至含有HAART方案的慢性抑制性NNRTI方案中对8例患者的CD4计数和激活标记物表达的影响。在强化的最初24周中，CD4计数显着增加（p = 0.028）。经过一年的随访，这种增加继续，每周CD4 T细胞的变化率达到0.959 +/- 1.27。此外，在强化过程中​​，CD38 + CD8 + T细胞百分比随时间的变化与CD4细胞数随时间的变化呈显着负相关，高于未经强化预测的增加（r（2）= 0.716，p = 0.008）。这些数据支持了在某些情况下发生CD4重建欠佳的情况，方案的强化会影响免疫学参数。

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