Patients suffering from acute graft-versus-host disease after bone-marrow transplantation have functional CD4+CD25hiFoxp3+ regulatory T cells.

Noel G; Bruniquel D; Birebent B; DeGuibert S; Grosset JM; Bernard M; Dauriac C; Chevallier P; Lamy-de-la-Chapelle T; Semana G; Brinster C

首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Patients suffering from acute graft-versus-host disease after bone-marrow transplantation have functional CD4+CD25hiFoxp3+ regulatory T cells.

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Patients suffering from acute graft-versus-host disease after bone-marrow transplantation have functional CD4+CD25hiFoxp3+ regulatory T cells.

机译：骨髓移植后患有急性移植物抗宿主病的患者具有功能性CD4 + CD25hiFoxp3 +调节性T细胞。

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Acute Graft-Versus-Host Disease (aGVHD), mediated by CD4(+) and CD8(+) effector T cells, is a life-threatening complication in hematopoietic stem cell (HSC) transplantation. Naturally-occurring CD4(+)CD25(hi)(Foxp3(+)) regulatory T cells (T(reg)) have been shown to modulate tolerance to aGVHD in murine graft models. In this report, we investigated their role in the prevention of aGVHD in patients transplanted with bone-marrow-derived HSC. When CD4(+)CD25(hi)Foxp3(+) T cells were isolated from bone-marrow grafts, they showed no suppressive activity. The analysis of their function in patients suffering from aGVHD after transplantation revealed a gain of suppressive activity indicating their inability to control the aGVHD induction. Thus, our findings clearly demonstrate that CD4(+)CD25(+) and CD4(+)CD25(hi)Foxp3(+) T cells, when administered in steady-state physiological conditions, do not influence the outcome of aGVHD after bone-marrow transplantation.

机译：CD4（+）和CD8（+）效应T细胞介导的急性移植物抗宿主病（aGVHD）是造血干细胞（HSC）移植中危及生命的并发症。天然存在的CD4（+）CD25（hi）（Foxp3（+））调节性T细胞（T（reg））已显示出可调节鼠移植模型对aGVHD的耐受性。在本报告中，我们调查了它们在预防骨髓源性HSC移植患者中预防aGVHD中的作用。当从骨髓移植物中分离出CD4（+）CD25（hi）Foxp3（+）T细胞时，它们没有抑制活性。对移植后患有aGVHD的患者的功能进行的分析显示，其抑制活性有所提高，表明他们无法控制aGVHD的诱导。因此，我们的发现清楚地表明，在稳态生理条件下给药时，CD4（+）CD25（+）和CD4（+）CD25（hi）Foxp3（+）T细胞不会影响骨转移后aGVHD的结果骨髓移植。

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来源
《Clinical immunology: The official journal of the Clinical Immunology Society》 |2008年第2期|共8页
作者
Noel G; Bruniquel D; Birebent B; DeGuibert S; Grosset JM; Bernard M; Dauriac C; Chevallier P; Lamy-de-la-Chapelle T; Semana G; Brinster C;
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正文语种 eng
中图分类医学免疫学;
关键词
Acute Disease; Adolescent; Adult; Aged; Bone Marrow Transplantation; Forkhead Transcription Factors;

机译：急性疾病;青少年;成人;年龄;骨髓移植;前额转录因子;

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1. Patients suffering from acute graft-versus-host disease after bone-marrow transplantation have functional CD4+CD25hiFoxp3+ regulatory T cells. [J] . Noel G, Bruniquel D, Birebent B, Clinical immunology: The official journal of the Clinical Immunology Society . 2008,第2期

机译：骨髓移植后患有急性移植物抗宿主病的患者具有功能性CD4 + CD25hiFoxp3 +调节性T细胞。
2. Impaired regulatory T cell reconstitution in patients with acute graft-versus-host disease and cytomegalovirus infection after allogeneic bone marrow transplantation [J] . NgomaA.M., IkedaK., HashimotoY., International journal of hematology . 2012,第1期

机译：同种异体骨髓移植后急性移植物抗宿主病和巨细胞病毒感染的患者调节性T细胞重建受损
3. Impaired regulatory T cell reconstitution in patients with acute graft-versus-host disease and cytomegalovirus infection after allogeneic bone marrow transplantation [J] . Alain M. Ngoma, Kazuhiko Ikeda, Yuko Hashimoto, International Journal of Hematology . 2012,第1期

机译：同种异体骨髓移植后急性移植物抗宿主病和巨细胞病毒感染的患者调节性T细胞重建受损
4. Anti-Thymocyte-Globulin (ATG-Fresenius) for Prevention of Acute and Chronic Graft-versus-Host Disease in Pediatric and Adult Recipients of Unrelated Donor Bone Marrow Transplantation [C] . . 2006

机译：抗胸腺细胞球蛋白（ATG-Fresenius）预防无关供体骨髓移植的小儿和成年患者的急性和慢性移植物抗宿主病
5. Antigen Specific Induced T Regulatory Cellular Therapy for Graft-Versus-Host Disease Following Allogeneic Bone Marrow Transplantation. [D] . Heinrichs, Jessica Lauren. 2016

机译：异体骨髓移植后针对移植物抗宿主病的抗原特异性诱导T调节细胞疗法。
6. Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood—a report from Eurocord the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation [O] . Frédéric Baron, Myriam Labopin, Annalisa Ruggeri, 2015

机译：成人急性髓细胞性白血病患者的无关脐带血移植：移植女性不相关脐带血的男性患者急性移植物抗宿主病的发生率较高而存活率较低— Eurocord急性白血病工作组和脐带血的报告欧洲血液和骨髓移植小组细胞治疗和免疫生物学委员会工作组
7. Soluble human leucocyte antigen-G molecules in peripheral blood haematopoietic stem cell transplantation: a specific role to prevent acute graft-versus-host disease and a link with regulatory T cells. [O] . Le Maux, Amélie, Noël, Gregory, Birebent, Brigitte, 2008

机译：外周血造血干细胞移植中的可溶性人白细胞抗原G分子：预防急性移植物抗宿主病的特定作用，并与调节性T细胞相关。

Patients suffering from acute graft-versus-host disease after bone-marrow transplantation have functional CD4+CD25hiFoxp3+ regulatory T cells.

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