Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.

Pfleger C; Kaas A; Hansen L; Alizadeh B; Hougaard P; Holl R; Kolb H; Roep BO; Mortensen HB; Schloot NC

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Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.

机译：1型糖尿病患者趋化因子受体CCR5配体的循环浓度与C肽，胰岛素原和HbA1c的关系以及疾病进展。

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Th1 related chemokines CCL3 and CCL5 and Th2 related CCL4 as ligands of the receptor CCR5 contribute to disease development in animal models of type 1 diabetes. In humans, no data are available addressing the role of these chemokines regarding disease progression and remission. We investigated longitudinally circulating concentrations of CCR5 ligands of 256 newly diagnosed patients with type 1 diabetes. CCR5 ligands were differentially associated with beta-cell function and clinical remission. CCL5 was decreased in remitters and positively associated with HbA1c suggestive of a Th1 associated progression of the disease. Likewise, CCL3 was negatively related to C-peptide and positively associated with the beta-cell stress marker proinsulin but increased in remitters. CCL4 associated with decreased beta-cell stress shown by negative association with proinsulin. Blockage of chemokines or antagonism of CCR5 by therapeutic agents such as maraviroc may provide a new therapeutic target to ameliorate disease progression in type 1 diabetes.

机译：Th1相关趋化因子CCL3和CCL5和Th2相关CCL4作为受体CCR5的配体有助于1型糖尿病动物模型中的疾病发展。在人类中，尚无数据可解决这些趋化因子在疾病进展和缓解方面的作用。我们调查了256位新诊断的1型糖尿病患者的CCR5配体的纵向循环浓度。 CCR5配体与β细胞功能和临床缓解差异相关。 CCL5在汇款者中减少，并与HbA1c正相关，提示该疾病与Th1相关。同样，CCL3与C肽负相关，与β细胞应激标志物胰岛素原正相关，但在缓解时增加。 CCL4与胰岛素原呈负相关，表明β细胞应激降低。诸如maraviroc之类的治疗剂对趋化因子的阻断或CCR5的拮抗作用可能为改善1型糖尿病的疾病发展提供新的治疗靶点。

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2008年第1期|共9页
作者
Pfleger C; Kaas A; Hansen L; Alizadeh B; Hougaard P; Holl R; Kolb H; Roep BO; Mortensen HB; Schloot NC;
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正文语种 eng
中图分类医学免疫学;
关键词
Adolescent; Biological Markers; C-Peptide; Chemokine CCL3; Chemokine CCL4; 生物学标记; C肽; 趋化因子类; 儿童; 儿童; 学龄前; 疾病恶化; 酶联免疫吸附测定;

机译：Adolescent;Biological Markers;C-Peptide;Chemokine CCL3;Chemokine CCL4;生物学标记;C肽;趋化因子类;儿童;儿童;学龄前;疾病恶化;酶联免疫吸附测定;

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1. Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes. [J] . Pfleger C, Kaas A, Hansen L, Clinical immunology: The official journal of the Clinical Immunology Society . 2008,第1期

机译：1型糖尿病患者趋化因子受体CCR5配体的循环浓度与C肽，胰岛素原和HbA1c的关系以及疾病进展。
2. Host genetic background at CCR5 chemokine receptor and vitamin D receptor loci and human immunodeficiency virus (HIV) type 1 disease progression among HIV-seropositive injection drug users. [J] . Barber Y, Rubio C, Fernandez E, The Journal of Infectious Diseases . 2001,第10期

机译：HIV血清阳性注射吸毒者中CCR5趋化因子受体和维生素D受体基因座以及人类免疫缺陷病毒（HIV）1型疾病进展的宿主遗传背景。
3. CC-chemokine receptor CCR5-del32 mutation as a modifying pathogenetic factor in type I diabetes. [J] . Kalev I, Oselin K, Parlist P, Journal of diabetes and its complications . 2003,第6期

机译：CC趋化因子受体CCR5-del32突变是I型糖尿病的致病因素。
4. Molecular and cellular regulation of the immune system: A study of Ikaros in Th2 cell lineage decisions and of mast cells' contribution to disease progression in a murine model of type 1 diabetes. [D] . Quirion, Mary Ryan. 2009

机译：免疫系统的分子和细胞调节：在1型糖尿病小鼠模型中，对Ikaros进行Th2细胞谱系决定以及肥大细胞对疾病进展的贡献的研究。
5. Distribution of Chemokine Receptor CCR2 and CCR5 Genotypes and Their Relative Contribution to Human Immunodeficiency Virus Type 1 (HIV-1) Seroconversion Early HIV-1 RNA Concentration in Plasma and Later Disease Progression [O] . Jianming Tang, Brent Shelton, Nina J. Makhatadze, 2002

机译：趋化因子受体CCR2和CCR5基因型的分布及其对人类免疫缺陷病毒1型（HIV-1）血清转化血浆中早期HIV-1 RNA浓度和后期疾病进展的相对贡献
6. Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes [O] . Pfleger, C, Kaas, A, Hansen, L, 2008

机译：1型糖尿病患者趋化因子受体CCR5配体循环浓度与C肽，胰岛素原和HbA1c的关系及疾病进展

Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.

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