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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >IVIg-mediated inhibition of antigen presentation: Predominant role of naturally occurring cationic IgG
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IVIg-mediated inhibition of antigen presentation: Predominant role of naturally occurring cationic IgG

机译：IVIg介导的抗原呈递抑制：天然阳离子IgG的主要作用

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摘要

The infusion of high doses of intravenous immunoglobulins (IVIg) produce anti-inflammatory effects in a diversity of autoimmune disorders. The need for such high doses suggests that only a small fraction of IgG is responsible for the anti-inflammatory effects. We recently showed that IVIg was internalized in APCs to compete with antigens for loading on MHC II molecules, leading to reduced antigen-specific T cell responses. Here we show that highly cationic IgG molecules present in IVIg are internalized more efficiently than IVIg in mouse P388D1 cells. We also show that the increased internalization correlates with the extent of inhibition of antigen presentation. Chemically cationized IVIg similarly showed improved internalization and inhibition of antigen presentation properties compared to IVIg. These observations suggest that highly cationic IgG are important mediators of the anti-inflammatory effects of IVIg resulting from inhibition of antigen presentation, such as the reduction in T cell activation and autoantibody production.
机译：大剂量静脉内免疫球蛋白（IVIg）的输注会在多种自身免疫性疾病中产生抗炎作用。对如此高剂量的需求表明，只有一小部分IgG负责抗炎作用。我们最近表明，IVIg已在APC中内化，可与抗原竞争装载在MHC II分子上，从而导致抗原特异性T细胞反应降低。在这里，我们显示在小鼠P388D1细胞中，存在于IVIg中的高阳离子IgG分子比IVIg更有效地内化。我们还表明，增加的内在化与抗原呈递的抑制程度有关。与IVIg相比，化学阳离子化的IVIg同样显示出更好的内在化和对抗原呈递特性的抑制。这些观察结果表明，高度阳离子的IgG是IVIg抗炎作用的重要介质，该作用是由于抑制抗原呈递而引起的，例如T细胞活化和自身抗体产生的减少。

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