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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells
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G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells

机译：人类供体中的G-CSF干细胞动员诱导多形核和单核髓样来源的抑制细胞

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The role of myeloid-derived suppressor cells (MDSC) is emerging in transplantation. An expansion of myeloid progenitor cells with suppressive capacity has been reported to occur as a bystander phenomenon in the course of allogeneic hematopoietic stem cell transplantation (allo-HSCT) protocols, particularly, in mice during bone marrow chimerism induction and in human stem cell donors during G-CSF-mobilization protocols. Hypothesizing that such 'regulatory myeloid cells' play a role in regulating post-transplant T-cell alloreactivity, we performed a phenotypical and functional characterization of these cells in peripheral blood stem cell grafts of G-CSF-treated donors. We demonstrate that expanding myeloid cells in the peripheral blood of G-CSF-mobilized donors comprise the typical phenotype of the mononuclear and polymorphonuclear MDSC-subtypes that were recently described in cancer patients, and that both MDSC-subsets have the capacity to regulate alloreactive T-cell responses in-vitro. This study provides the basis for investigating the clinical relevance of MDSC and MDSC-subtypes in human allo-HSCT.
机译：骨髓来源的抑制细胞（MDSC）的作用正在移植中出现。据报道，在同种异体造血干细胞移植（allo-HSCT）方案的过程中，旁观者发生了具有抑制能力的骨髓祖细胞的扩增，特别是在骨髓嵌合诱导的小鼠和人类干细胞供体在此期间。 G-CSF动员协议。假设此类“调节性髓样细胞”在调节移植后T细胞同种反应性中起作用，我们在G-CSF治疗的供体的外周血干细胞移植物中进行了这些细胞的表型和功能表征。我们证明，在G-CSF动员的捐献者外周血中扩增的髓样细胞包括最近在癌症患者中描述的单核和多形核MDSC亚型的典型表型，并且两个MDSC亚集都具有调节同种反应性T的能力。细胞体外反应。该研究为研究人同种异体HSCT中MDSC和MDSC亚型的临床相关性提供了基础。

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