• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Increased Th17 response to myelin peptides in pediatric MS
【24h】

Increased Th17 response to myelin peptides in pediatric MS

机译：小儿MS对髓鞘肽的Th17反应增加

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Studies of the underlying immune mechanisms of multiple sclerosis (MS) in children may shed light on the initial events of MS pathogenesis. We studied T cell responses to myelin peptides in 10 pediatric MS patients (PMS), 10 pediatric healthy controls (PHC), 10 adult MS patients (AMS) and 10 adult healthy controls (AHC). A significantly higher proportion of divided CD4. + T cell responses in response to myelin peptides by the CFSE assay in PMS compared to PHC at both concentrations of myelin peptide tested (t test, 95% CI, p = 0.0067 for MP1; p = 0.0086 for MP10), and between PMS and AMS (p = 0.0012 at 1. μg/mL of myelin peptides, p. <0.0001 at 10. μg/mL) was found. In addition, T cells with a central memory phenotype producing IL-17 were increased in PMS compared to PHC (p. <0.05). IL-7 levels in culture supernatants were elevated in PMS compared to PHC and AMS (t test. <0.01).
机译：对儿童多发性硬化症（MS）潜在免疫机制的研究可能为MS发病机制的初始事件提供了启示。我们研究了10名儿科MS患者（PMS），10名儿科健康对照（PHC），10名成年MS患者（AMS）和10名成年健康对照（AHC）对T细胞对髓磷脂肽的反应。分割CD4的比例明显更高。在两种浓度的髓磷脂肽（t检验，95％CI，对于MP1，p = 0.0067;对于MP10，p = 0.0086）和在PMS与发现AMS（在1.μg/ mL髓磷脂肽下p = 0.0012，在10μg/ mL时p。<0.0001）。此外，与PHC相比，PMS中具有产生IL-17的中央记忆表型的T细胞增加（p。<0.05）。与PHC和AMS相比，PMS中培养上清液中的IL-7水平升高（t检验，<0.01）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号