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首页> 外文期刊>Journal of psychiatric research >Effects of mirtazapine on dehydroepiandrosterone-sulfate and cortisol plasma concentrations in depressed patients.
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Effects of mirtazapine on dehydroepiandrosterone-sulfate and cortisol plasma concentrations in depressed patients.

机译：米氮平对抑郁症患者脱氢表雄酮硫酸盐和皮质醇血浆浓度的影响。

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BACKGROUND: Among the neuroactive steroids, dehydroepiandrosterone sulfate (DHEA-S) is at least in part produced in the adrenal gland and is therefore under the control of the hypothalamic-pituitary-adrenocortical (HPA)-system. In the present study, the impact of mirtazapine on DHEA-S and cortisol (COR) levels was investigated in relation to clinical response in depressed patients. METHODS: A total of 23 inpatients suffering from a major depressive episode (DSM-IV criteria) underwent 5-week treatment with mirtazapine (45 mg/day). Plasma samples were taken weekly at 0800 h and quantified for COR and DHEA-S levels. RESULTS: Mirtazapine significantly reduced both COR and DHEA-S concentrations, but had no impact on the COR/DHEA-S ratio. The percentage decrease of DHEA-S, but not that of COR was significantly and positively correlated with the percentage reduction in the sum score of the Hamilton Depression Rating Scale at week 5, suggesting a relationship between DHEA-S reduction and clinical efficacy of mirtazapine. There was a significant positive correlation between the decline in COR and DHEA-S levels. CONCLUSIONS: Apparently, the decrease in COR and DHEA-S concentrations conjointly reflects an attenuating impact of mirtazapine on HPA axis activity, thereby decreasing the adrenal secretion of COR and DHEA-S.
机译：背景：在神经活性类固醇中，硫酸脱氢表雄酮（DHEA-S）至少部分在肾上腺中产生，因此处于下丘脑-垂体-肾上腺皮质（HPA）系统的控制之下。在本研究中，研究了米氮平对DHEA-S和皮质醇（COR）水平的影响与抑郁症患者的临床反应之间的关系。方法：总共23名患有严重抑郁发作（DSM-IV标准）的住院患者接受了米氮平（45 mg /天）的5周治疗。每周在0800 h采集血浆样品，并对COR和DHEA-S水平进行定量。结果：米氮平显着降低了COR和DHEA-S的浓度，但对COR / DHEA-S的比例没有影响。 DHEA-S降低的百分比（而不是COR降低的百分比）与汉密尔顿抑郁量表的总分降低的百分比在第5周呈显着正相关，表明DHEA-S降低与米氮平的临床疗效之间存在关联。 COR和DHEA-S水平的下降之间存在显着的正相关。结论：显然，COR和DHEA-S浓度的降低共同反映了米氮平对HPA轴活性的减弱作用，从而降低了COR和DHEA-S的肾上腺分泌。

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