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首页> 外文期刊>Journal of psychiatric research >The effects of lisdexamfetamine dimesylate on the driving performance of young adults with ADHD: A randomized, double-blind, placebo-controlled study using a validated driving simulator paradigm
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The effects of lisdexamfetamine dimesylate on the driving performance of young adults with ADHD: A randomized, double-blind, placebo-controlled study using a validated driving simulator paradigm

机译：赖氨苯丙胺二甲磺酸酯对患有ADHD的年轻人的驾驶性能的影响：一项使用经过验证的驾驶模拟器范例进行的随机，双盲，安慰剂对照研究

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摘要

Young adults with Attention Deficit Hyperactivity Disorder (ADHD) have been shown to be at increased risk for impairment in driving behaviors. While stimulant medications have proven efficacy in reducing ADHD symptomatology, there is limited knowledge as to their effects on driving impairment. The main aim of this study was to assess the impact of lisdexamfetamine dimesylate (LDX) on driving performance in young adults with ADHD using a validated driving simulation paradigm. This was a randomized, double-blind, 6-week, placebo-controlled, parallel-design study of LDX vs. a placebo on driving performance in a validated driving simulation paradigm. Subjects were sixty-one outpatients of both sexes, 18-26 years of age, who met DSM-IV criteria for ADHD. Subjects were randomized to receive LDX or placebo after a baseline driving simulation and completed a second driving simulation six weeks after beginning drug or placebo. Examination of reaction time across five surprise events at post-treatment showed a significant positive effect of medication status. LDX treatment was also associated with significantly fewer accidents vs. placebo. LDX treatment was associated with significantly faster reaction times and a lower rate of simulated driving collisions than placebo. These results suggest that LDX may reduce driving risks in young adults with ADHD.
机译：已显示患有注意力缺陷多动障碍（ADHD）的年轻人驾驶行为受损的风险增加。尽管兴奋剂已被证明能有效减轻ADHD症状，但对其对驾驶障碍的影响知之甚少。这项研究的主要目的是使用经过验证的驾驶模拟范例，评估赖氨苯丙胺二甲磺酸酯（LDX）对ADHD年轻人的驾驶性能的影响。这是LDX与安慰剂在一项经过验证的驾驶模拟范例中进行的一项随机，双盲，为期6周，安慰剂对照，并行设计的研究。受试者为六十一名年龄在18-26岁之间的男女门诊患者，均符合DSM-IV的ADHD标准。在基线驾驶模拟后将受试者随机接受LDX或安慰剂，并在开始药物或安慰剂治疗六周后完成第二次驾驶模拟。治疗后五个意外事件中反应时间的检查显示出药物状态的显着积极影响。与安慰剂相比，LDX治疗还减少了事故。与安慰剂相比，LDX治疗具有显着更快的反应时间和更低的模拟驾驶碰撞率。这些结果表明，LDX可以降低患有ADHD的年轻人的驾驶风险。

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