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首页> 外文期刊>Journal of psychiatric research >Association of plasma omega-3 and omega-6 lipids with burden of disease measures in bipolar subjects
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Association of plasma omega-3 and omega-6 lipids with burden of disease measures in bipolar subjects

机译：躁郁症患者血浆omega-3和omega-6脂质与疾病负担的关系

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Omega-3 (n-3) fatty acids have been implicated in mood disorders, yet clinical trials supplementing n-3 fats have shown mixed results. However, the predominant focus of this research has been on the n-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). We used an unbiased approach to assay plasma n-3 and omega-6 (n-6) species that interact at the level of biosynthesis and down-stream processing, to affect brain function and, potentially, mood. We used lipomic technology to assay plasma levels of n-3 and n-6 fatty acids from 40 bipolar and 18 control subjects to investigate differences in plasma levels and associations with the burden of disease markers, neuroticism and global assessment of function (GAF) and mood state (Hamilton Depression Scale (HAM-D)). Most significantly, we found the levels of dihomo-gamma-linolenic acid (DGLA) to positively correlate with neuroticism and HAM-D scores and negatively correlate with GAF scores; and HAM-D to negatively correlate with linoleic acid (LA) and positively correlate with fatty acid desaturase 2 (FADS2) activity, an enzyme responsible for converting LA to gamma-linolenic acid (GLA). These associations remained significant following Bonferroni multiple testing correction. These data suggest that specific n-6 fatty acids and the enzymes that control their biosynthesis may be useful biomarkers in measurements of depressive disorders and burden of disease, and that they should be considered when investigating the roles of n-3s.
机译：Omega-3（n-3）脂肪酸与情绪障碍有关，但补充n-3脂肪的临床试验却显示出不同的结果。但是，这项研究的主要重点是n-3脂肪酸二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）。我们使用无偏方法来分析血浆n-3和omega-6（n-6）物种，这些物种在生物合成和下游加工的水平上相互作用，从而影响大脑功能，甚至可能影响情绪。我们使用脂质学技术分析了40位双相和18位对照受试者的血浆n-3和n-6脂肪酸水平，以研究血浆水平的差异以及与疾病标志物，神经质和功能总体评估（GAF）负担的关系。情绪状态（汉密尔顿抑郁量表（HAM-D））。最重要的是，我们发现二高-γ-亚麻酸（DGLA）的水平与神经质和HAM-D得分呈正相关，与GAF得分呈负相关。和HAM-D与亚油酸（LA）呈负相关，与脂肪酸去饱和酶2（FADS2）活性呈正相关，该酶负责将LA转化为γ-亚麻酸（GLA）。在Bonferroni多次测试校正后，这些关联仍然很重要。这些数据表明，特定的n-6脂肪酸和控制其生物合成的酶可能是测量抑郁症和疾病负担的有用生物标志物，在研究n-3s的作用时应考虑它们。

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