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首页> 外文期刊>Journal of psychiatric research >Sex determines which section of the SLC6A4 gene is linked to obsessive-compulsive symptoms in normal Chinese college students
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Sex determines which section of the SLC6A4 gene is linked to obsessive-compulsive symptoms in normal Chinese college students

机译：性别决定了普通中国大学生中SLC6A4基因的哪一部分与强迫症相关

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摘要

Previous case-control and family-based association studies have implicated the SLC6A4 gene in obsessive-compulsive disorder (OCD). Little research, however, has examined this gene's role in obsessive-compulsive symptoms (OCS) in community samples. The present study genotyped seven tag SNPs and two common functional tandem repeat polymorphisms (5-HTTLPR and STin2), which together cover the whole SLC6A4 gene, and investigated their associations with OCS in normal Chinese college students (N = 572). The results revealed a significant gender main effect and gender-specific genetic effects of the SLC6A4 gene on OCS. Males scored significantly higher on total OCS and its three dimensions than did females (ps <01). The 5-HTTLPR in the promoter region showed a female-specific genetic effect, with the l/l and l/s genotypes linked to higher OCS scores than the s/s genotype (ps <05). In contrast, a conserved haplotype polymorphism (rs1042173| rs4325622| rs3794808| rs140701| rs4583306| rs2020942) covering from intron 3 to the 3' UTR of the SLC6A4 gene showed male-specific genetic effects, with the CGAAGG/CGAAGG genotype associated with lower OCS scores than the other genotypes (ps <05). These effects remained significant after controlling for OCS-related factors including participants' depressive and anxiety symptoms as well as stressful life events, and correction for multiple tests. These results are discussed in terms of their implications for our understanding of the sex-specific role of the different sections of the SLC6A4 gene in OCD.
机译：以前的病例对照和基于家庭的关联研究已将SLC6A4基因牵涉到强迫症（OCD）中。然而，很少有研究检查该基因在社区样本中的强迫症（OCS）中的作用。本研究对7个标签SNP和两个常见的功能性串联重复多态性（5-HTTLPR和STin2）进行了基因分型，它们共同覆盖了整个SLC6A4基因，并调查了它们与正常中国大学生中OCS的关联（N = 572）。结果显示，SLC6A4基因对OCS具有重要的性别主效应和性别特异性遗传效应。男性在总OCS及其三个维度上的得分明显高于女性（ps <01）。启动子区域的5-HTTLPR显示出女性特有的遗传效应，其中l / l和l / s基因型与s / s基因型相关的OCS得分更高（ps <05）。相反，从内含子3到SLC6A4基因的3'UTR的保守单倍型多态性（rs1042173 | rs4325622 | rs3794808 | rs140701 | rs4583306 | rs2020942）显示出男性特异性的遗传效应，其中CGAAGG / CGAAGG基因型与较低的OCS相关得分高于其他基因型（ps <05）。在控制了与OCS相关的因素（包括参与者的抑郁和焦虑症状以及压力性生活事件以及多项测试的校正）后，这些效果仍然很明显。讨论了这些结果对我们理解强迫症中SLC6A4基因不同部分的性别特异性作用的意义。

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