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首页> 外文期刊>Journal of psychiatric research >Bedwell, J.S.a , Chan, C.C.a , Trachik, B.J.a , Rassovsky, Y.b c Changes in the visual-evoked P1 potential as a function of schizotypy and background color in healthy young adults
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Bedwell, J.S.a , Chan, C.C.a , Trachik, B.J.a , Rassovsky, Y.b c Changes in the visual-evoked P1 potential as a function of schizotypy and background color in healthy young adults

机译：Bedwell，J.S.a，Chan，C.C.a，Trachik，B.J.a，Rassovsky，Y.b c健康年轻人中视觉诱发的P1电位随精神分裂症和背景颜色的变化

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Research has suggested a hypoactive visual magnocellular (M) pathway in individuals with schizophrenia-spectrum disorders and traits, along with a unique response of this pathway to red light. As these abnormalities only appear in a subset of these samples, they may reflect unknown subtypes with unique etiologies and corresponding neuropathologies. The P1 transient visual-evoked component has been found to be influenced by M-pathway activity; therefore, the current study assessed the P1 component in response to a 64% contrast checker stimulus on white, red, and green background conditions. The sample consisted of 28 undergraduate participants (61% male) who endorsed a continuous range of total scores from the Schizotypal Personality Questionnaire (SPQ). Participants with higher total SPQ scores had a reduced P1 mean amplitude with the white (baseline) background, which was primarily related to the SPQ Magical Thinking subscale score. In addition, while participants with lower total SPQ scores showed the expected reduction in P1 amplitude to the red (vs. green) background, participants with higher total SPQ scores showed no change, which was primarily related to the SPQ Ideas of Reference subscale. This differential change to the red background remained after covarying for the P1 amplitude to the green background, thus representing a relatively independent effect. Further confirmation of these early visual processing relationships to particular clusters of symptoms in related psychiatric samples may assist in revealing unique, currently unknown, subtypes of particular psychiatric disorders such as schizophrenia. This can direct treatment efforts toward more homogeneous neuropathology targets. ? 2012 Elsevier Ltd.
机译：研究表明，患有精神分裂症-频谱疾病和特征的人存在视觉活跃的视觉巨细胞（M）通路，以及该通路对红光的独特反应。由于这些异常仅出现在这些样本的子集中，它们可能反映出具有独特病因和相应神经病理学的未知亚型。已发现P1短暂性视觉诱发因素受M通路活性的影响。因此，当前的研究评估了在白色，红色和绿色背景条件下响应64％对比度检查器刺激时的P1成分。该样本由28名本科生参与者（61％的男性）组成，他们认可了Schizotypal人格问卷（SPQ）的连续总评分范围。总体SPQ得分较高的参与者在白色（基线）背景下的P1平均振幅降低，这主要与SPQ魔术思维子量表得分有关。此外，虽然总SPQ得分较低的参与者表现出预期的P1振幅下降到红色（相对于绿色）背景，但总SPQ分数较高的参与者没有表现出变化，这主要与SPQ参考观念量表有关。在将P1振幅向绿色背景变化后，仍保留了向红色背景的这种差异变化，因此代表了相对独立的效果。这些早期视觉处理与相关精神病学样本中特定症状群的早期视觉处理关系的进一步确认可能有助于揭示特定精神病（例如精神分裂症）的独特，当前未知的亚型。这可以将治疗工作指向更均匀的神经病理学目标。 ？ 2012爱思唯尔有限公司

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