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首页> 外文期刊>Journal of psychiatric research >Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation: A near-infrared spectroscopy study
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Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation: A near-infrared spectroscopy study

机译：精神分裂症患者面对面交谈时的颞叶和额下前叶功能障碍：一项近红外光谱研究

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Schizophrenia (SC) is marked by poor social-role performance and social-skill deficits that are well reflected in daily conversation. Although the mechanism underlying these impairments has been investigated by functional neuroimaging, technical limitations have prevented the investigation of brain activation during conversation in typical clinical situations. To fill this research gap, this study investigated and compared frontal and temporal lobe activation in patients with SC during face-to-face conversation. Frontal and temporal lobe activation in 29 patients and 31 normal controls (NC) (n=60) were measured during 180-s conversation periods by using near-infrared spectroscopy (NIRS). The grand average values of oxyhemoglobin concentration ([oxy-Hb]) changes during task performance were analyzed to determine their correlation with clinical variables and Positive and Negative Syndrome Scale (PANSS) subscores. Compared to NCs, patients with SC exhibited decreased performance in the conversation task and decreased activation in both the temporal lobes and the right inferior frontal gyrus (IFG) during task performance, as indicated by the grand average of [oxy-Hb] changes. The decreased activation in the left temporal lobe was negatively correlated with the PANSS disorganization and negative symptoms subscores and that in the right IFG was negatively correlated with illness duration, PANSS disorganization, and negative symptom subscores. These findings indicate that brain dysfunction in SC during conversation is related to functional deficits in both the temporal lobes and the right IFG and manifests primarily in the form of disorganized thinking and negative symptomatology.
机译：精神分裂症（SC）的特征是不良的社交角色表现和社交技能缺陷，这些都很好地反映在日常对话中。尽管已经通过功能性神经影像学研究了这些障碍的潜在机制，但是技术限制已经阻止了在典型临床情况下谈话过程中大脑激活的研究。为了填补这一研究空白，本研究调查并比较了面对面交谈中SC患者的额叶和颞叶活化。通过使用近红外光谱（NIRS）在180 s的对话期内测量了29位患者和31位正常对照（NC）（n = 60）的额叶和颞叶活化。分析任务执行过程中氧合血红蛋白浓度（[oxy-Hb]）变化的总体平均值，以确定它们与临床变量以及阳性和阴性综合症量表（PANSS）子评分的相关性。与NCs相比，SC患者在谈话任务中表现出降低的表现，在任务执行过程中，颞叶和右下额回（IFG）的激活均降低，如[oxy-Hb]变化的总体平均值所示。左侧颞叶的激活减少与PANSS紊乱和阴性症状分数负相关，而右侧IFG与疾病持续时间，PANSS紊乱和阴性症状分数负相关。这些发现表明，会话过程中SC的脑功能障碍与颞叶和右侧IFG的功能缺陷有关，并且主要表现为思维混乱和症状消极的形式。

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