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首页> 外文期刊>Journal of psychiatric research >A population-based association study of 2q32.3 and 8q21.3 loci with schizophrenia in Han Chinese
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A population-based association study of 2q32.3 and 8q21.3 loci with schizophrenia in Han Chinese

机译：汉族人群中2q32.3和8q21.3基因座与精神分裂症的人群关联研究

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摘要

It has been reported that two new schizophrenia susceptibility loci (2q32.3 and 8q21.3) containing two single-nucleotide polymorphisms (SNPs; rs17662626 and rs7004633) have been identified in Europeans by a genome-wide association study. To determine if the two regions are associated with schizophrenia in Han Chinese, which are distinct from Europeans, we analyzed 9 SNPs, including rs17662626 and rs7004633, within 2 regions involving 1430 cases and 1570 controls from the Han population. Single SNP association, haplotype association, and gender-specific association analyses were performed. Single SNP analyses revealed that there was no association with schizophrenia in the region of 2q32.3, but rs7004633 mapping to the region of 8q21.3 was significantly associated with schizophrenia (p = 5.1 × 10-5; OR = 1.274; 95% CI, 1.134-1.429). Further genotype and haplotype association analyses for the region of 8q21.3 suggested a similar pattern. Additionally, analyses by haplotypes indicated that a haplotype block in the region of 8q21.3 highly associated with schizophrenia and one haplotype in this haploblock had a 1.5-fold increase in the cases. Our results provide further evidence regarding the association of the region of 8q21.3 with schizophrenia in Han Chinese, as well as Europeans, which confirmed the previous report that 8q21.3 may play important roles in the etiology of schizophrenia.
机译：据报道，欧洲人通过全基因组关联研究确定了两个新的精神分裂症易感基因座（2q32.3和8q21.3），其中包含两个单核苷酸多态性（SNP; rs17662626和rs7004633）。为了确定这两个地区是否与汉族人（与欧洲人不同）与精神分裂症有关，我们在两个地区中分析了9个SNP，包括rs17662626和rs7004633，涉及来自汉族的1430例病例和1570例对照。进行了单SNP关联，单倍型关联和特定性别的关联分析。单个SNP分析显示2q32.3区域与精神分裂症没有关联，但是rs7004633映射到8q21.3区域与精神分裂症显着相关（p = 5.1×10-5; OR = 1.274; 95％CI ，1.134-1.429）。进一步的基因型和单倍型关联分析的8q21.3区域建议类似的模式。此外，通过单倍型分析表明，与精神分裂症高度相关的8q21.3区域中的一个单倍型模块和该单倍模块中的一个单倍型在这种情况下增加了1.5倍。我们的结果提供了关于汉族人和欧洲人中8q21.3区域与精神分裂症的关联的进一步证据，这证实了先前的报道，即8q21.3可能在精神分裂症的病因中起重要作用。

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