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首页> 外文期刊>Journal of psychiatric research >BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder
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BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder

机译：BDNF Val66Met可改善强迫症对儿童造成创伤的风险

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摘要

Childhood trauma has been linked to the development of later psychopathology, including obsessive-compulsive disorder (OCD). Although evidence exists to suggest that genetic and environmental factors are involved in the aetiology of OCD, little attention has been paid to the interactions that exist between genes and environment. The aim of this study was to investigate gene-by-environment interactions between childhood trauma and the BDNF Val66Met variant in patients with OCD. Childhood trauma was assessed in 134 OCD patients and 188 controls using the Childhood Trauma Questionnaire (CTQ). Linear regression models were used for statistical analyses. Gene-environment interactions were estimated by including a combined genotype and CTQ score in the models as interaction terms. All analyses were adjusted for age, gender, CTQ minimisation-denial score and home language by including them in the logistic regression models as covariates. Childhood trauma, specifically emotional abuse and neglect, increased the odds of having OCD significantly ( p<0.001). Although no significant association was observed between BDNF Val66Met and the development of OCD, interaction analysis indicated that the BDNF Met-allele interacted with childhood emotional abuse to increase the risk of OCD significantly in a dose-dependent manner ( p=0.024). To our knowledge, this is one of the first studies to investigate gene-environment interactions in OCD, and the findings indicate the importance of collating genetic and environmental variables in future studies.
机译：童年创伤与后来的心理病理学发展有关，包括强迫症（OCD）。尽管有证据表明遗传因素和环境因素与强迫症的病因有关，但很少关注基因与环境之间存在的相互作用。这项研究的目的是调查强迫症患者儿童期创伤与BDNF Val66Met变体之间的基因-环境相互作用。使用儿童创伤问卷（CTQ）评估了134名强迫症患者和188名对照组的儿童创伤。线性回归模型用于统计分析。通过在模型中加入基因型和CTQ得分作为交互项来估计基因与环境的交互作用。通过将所有分析作为协变量纳入逻辑回归模型，对所有分析进行了年龄，性别，CTQ最小化拒绝分数和家庭语言的调整。童年的创伤，特别是情感上的虐待和忽视，大大增加了强迫症的发生几率（p <0.001）。尽管在BDNF Val66Met和OCD的发生之间未发现显着相关性，但相互作用分析表明BDNF Met等位基因与儿童情感虐待相互作用，以剂量依赖性方式显着增加了OCD的风险（p = 0.024）。据我们所知，这是最早研究强迫症中基因与环境相互作用的研究之一，研究结果表明在未来的研究中整理遗传和环境变量的重要性。

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