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首页> 外文期刊>Journal of psychiatry & neuroscience: JPN >Aberrant cortical gyrification in schizophrenia: A surface-based morphometry study
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Aberrant cortical gyrification in schizophrenia: A surface-based morphometry study

机译：精神分裂症的异常皮质回旋：基于表面的形态学研究

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Background: Schizophrenia is considered to be a disorder of cerebral connectivity associated with disturbances of cortical development. Disturbances in connectivity at an early period of cortical maturation can result in widespread defects in gyrification. Investigating the anatomic distribution of gyrification defects can provide important information about neurodevelopment in patients with schizophrenia. Methods: We undertook an automated surface-based morphometric assessment of gyrification on 3-dimensionally reconstructed cortical surfaces across multiple vertices that cover the entire cortex. We used a sample from our previous research of 57 patients (50 men) with schizophrenia and 41 controls (39 men) in whom we had tested a specific hypothesis regarding presence of both hypoand hypergyria in the prefrontal cortex using a frontal region-of-interest approach. Results: Regions with significant reductions in gyrification (hypogyria) were seen predominantly in the left hemisphere, involving the insula and several regions of the multimodal association cortex. Although the prefrontal hypergyria documented earlier did not survive the statistical correction required for a whole brain search (cluster inclusion at p = 0.0001), significant hypergyric frontal clusters emerged when the threshold was lowered (cluster inclusion at p = 0.05). In the insula, a reduction in gyrification was related to reduced cortical thickness in patients with schizophrenia. Limitations: We studied a sample of patients taking antipsychotic medications, which could have confounded the results. Our sample was predominantly male, limiting the generalizability of our findings. Conclusion: Our observations suggest that the disturbances in cortical gyrification seen in patients with schizophrenia might be related to a disrupted interaction between the paralimbic and the multimodal association cortex and thus might contribute to the pathogenesis of the illness.
机译：背景：精神分裂症被认为是与大脑皮质发育障碍相关的大脑连接障碍。在皮质成熟的早期阶段，连接性的紊乱会导致回旋的广泛缺陷。调查回旋缺陷的解剖分布可以提供有关精神分裂症患者神经发育的重要信息。方法：我们对覆盖整个皮质的多个顶点的3维重建皮质表面进行了基于表面的自动化形态学评估回旋。我们使用先前研究的样本，对57位精神分裂症患者（50名男性）和41位对照（39位男性）进行了研究，其中我们使用了一个感兴趣的额叶区域，测试了关于额叶皮层中同时存在hypohypergy和hypergyria的特定假设。方法。结果：主要在左半球见到回旋（低脑回旋）明显减少的区域，涉及绝缘岛和多峰联合皮层的多个区域。尽管较早文献中记载的前额叶高亢并不能幸免于全脑搜索所需的统计校正（p = 0.0001时的团簇夹杂物），但当阈值降低时（p = 0.05时的团簇夹杂物）会出现明显的高回额性额叶簇。在岛上，精神分裂症患者的回旋减少与皮层厚度减少有关。局限性：我们研究了服用抗精神病药物的患者样本，这可能会使结果混淆。我们的样本主要是男性，这限制了我们研究结果的普遍性。结论：我们的观察结果表明，精神分裂症患者的皮质回旋障碍可能与上肢和多峰联合皮层之间的相互作用受阻有关，因此可能与疾病的发病机理有关。

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