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首页> 外文期刊>Journal of psychiatry & neuroscience: JPN >Decreased cognitive control in response to negative information in patients with remitted depression: An event-related potential study
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Decreased cognitive control in response to negative information in patients with remitted depression: An event-related potential study

机译：缓解抑郁症患者对不良信息的认知控制能力下降：一项与事件相关的潜在研究

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Background: Major depressive disorder (MDD) is associated with difficulty disengaging attention from emotionally negative information. Few studies have investigated whether euthymic individuals with a history of depression (remitted MDD [rMDD]) show similar deficits, and little is known about concomitant neurophysiological features of such deficits. To fill these gaps, we investigated cognitive control over emotional stimuli in participants with rMDD and controls without history of depression or psychopathology. Methods: We collected 128- channel event-related potentials (ERPs) while participants performed a cued emotional conflict task. During the task, a cue instructed the participant to respond to the actual or opposite valence of an upcoming happy or sad face. Results: We enrolled 15 individuals with rMDD and 18 controls in our study. Event-related potentials showed no group differences in response to the cues, highlighting preserved preparatory processes when anticipating an emotional conflict. However, relative to the control group, the rMDD group responded more slowly and showed reduced N450 amplitudes on trials that required disengaging from negative faces (pressing "happy" in response to a sad face). Limitations: The sample size was small, and the null finding in the cue-locked N2 analyses may be owing to low power. C onclusion: Our results suggest a selective deficit in cognitive control over sad stimuli in individuals with rMDD. Additional studies will be required to pinpoint whether the current findings stem from impairments in response conflict, conflict monitoring and/or at-tentional disengagement in response to sad stimuli. Moreover, future studies are warranted to evaluate whether decreased cognitive control in response to negative information might increase the risk for future depressive episodes.
机译：背景：重度抑郁症（MDD）与难以将注意力从情绪负面信息中分离出来有关。很少有研究调查有抑郁史（缓解的MDD [rMDD]）的正常人个体是否显示出类似的缺陷，并且对这种缺陷的伴随神经生理学特征知之甚少。为了填补这些空白，我们调查了患有rMDD的参与者对情绪刺激的认知控制以及没有抑郁或心理病理史的控制。方法：当参与者执行提示的情绪冲突任务时，我们收集了128个通道的事件相关电位（ERP）。在任务过程中，提示指示参与者对即将到来的开心或悲伤表情的实际价或相反价做出响应。结果：我们在研究中招募了15名具有rMDD的个体和18名对照。与事件相关的电位对线索的反应没有表现出群体差异，突显了预期的情感冲突时保留的准备过程。但是，相对于对照组，rMDD组的反应更为缓慢，并且在需要从负面面孔脱开的试验中显示出N450振幅降低（对悲伤面孔做出回应时“高兴”）。局限性：样本量很小，提示锁定N2分析中的无效发现可能归因于低功率。结论：我们的研究结果表明，rMDD患者对悲伤刺激的认知控制存在选择性缺陷。将需要进行进一步的研究以查明当前的发现是否源于响应冲突，冲突监测和/或因悲伤刺激而引起的注意力脱离。此外，有必要进行进一步的研究来评估对负面信息的认知控制能力下降是否会增加未来抑郁发作的风险。

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