...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychiatry & neuroscience: JPN >Stress response in postpartum women with and without obsessive-compulsive symptoms: An fmri study
【24h】

Stress response in postpartum women with and without obsessive-compulsive symptoms: An fmri study

机译：fmri研究：有和没有强迫症的产后妇女的压力反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: During the postpartum period, some women might be under a considerable amount of stress and at increased risk for onset or exacerbation of obsessive-compulsive disorder (OCD). Little is known about the stress response correlates during the postpartumperiod and in patients with OCD. This study aimed to examine the cerebral, psychologic and endocrine correlates of the stress response in patients with OCD and during the postpartum period. Methods: Women with postpartum OCD, healthy postpartum women and healthy mothers past the postpartum period underwent functional magnetic resonance imaging while facing a reliable psychosocial stressor (the Montreal Imaging Stress Task). Stress-related psychologic and endocrine responses (i.e., cortisol) were obtained. Results: We enrolled 12 women with postpartum OCD, 16 healthy postpartum women and 11 healthy mothers past the postpartum period in our study. Compared with healthy postpartum counterparts, postpartum women with OCD had a he ightened self-reported and endocrine stress response associated with a distinct brain activation pattern in response to psychosocial stress involving the orbitofrontal and temporal cortices. Moreover, compared with mothers assessed in a period of time beyond the postpartum period, healthy postpartum women did not differ in psychologic and cortisol response to stress, but recruited different brain regions, such as the dorsolateral prefrontal cortex and the anterior cingulate cortex, during exposure to stress. Limitations: Potential confounding factors, such as medication use, breastfeeding, parity and personality factors, may have modulated the stress-related endocrine response and could not be assessed in this study. Conclusion: Obsessive-compulsive disorder and the postpartum period differentially influence the brain circuitry underlying psychosocial stress as well as the psychologic and endocrine responses.
机译：背景：在产后时期，一些妇女可能承受着相当大的压力，并且强迫症（OCD）发作或恶化的风险增加。产后和强迫症患者的应激反应相关知之甚少。这项研究旨在检查强迫症患者和产后应激反应的大脑，心理和内分泌相关性。方法：患有产后强迫症的妇女，产后健康的妇女和产后健康的母亲，在面对可靠的社会心理压力源的同时，接受了功能性磁共振成像（蒙特利尔影像应激任务）。获得了与压力有关的心理和内分泌反应（即皮质醇）。结果：我们纳入了12名产后强迫症的妇女，16名健康的产后妇女和11名健康的产后妇女。与健康的产后同龄人相比，患有强迫症的产后妇女的自报性和内分泌应激反应增强，与涉及眶额和颞皮质的心理社会应激反应有关，大脑的激活模式也不同。此外，与产后以外的一段时间内进行评估的母亲相比，健康的产后妇女在压力下的心理和皮质醇反应没有差异，但是在暴露期间募集了不同的大脑区域，例如背外侧前额叶皮层和前扣带皮层强调。局限性：潜在的混杂因素，例如药物使用，母乳喂养，均等和人格因素，可能已经调节了与压力有关的内分泌反应，因此无法在本研究中进行评估。结论：强迫症和产后时期对心理社会压力以及心理和内分泌反应的脑回路有不同的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号