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首页> 外文期刊>Journal of psychiatry & neuroscience: JPN >Morphometric differences in central stress-regulating structures between women with and without borderline personality disorder
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Morphometric differences in central stress-regulating structures between women with and without borderline personality disorder

机译：有和没有边缘性人格障碍的女性之间中央压力调节结构的形态学差异

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Background: Experiences of early life stress, increased psychological arousal and the body's physiologic stress response seem to play an important role in the pathogenesis and maintenance of borderline personality disorder (BPD). In the present study, we investigated alterations in grey matter of central stress-regulating structures in female patients with BPD. Methods: We examined T1-weighted structural magnetic resonance imaging scans of unmedicated, right-handed female patients with BPD (according to DSM-IV criteria) and healthy controls matched for age, intelligence and education using fully automated DARTEL voxel-based morphometry. Our regions of interest analyses included the hippocampus, amygdala, anterior cingulate cortex (ACC) and hypothalamus. Results: We enrolled 30 patients and 33 controls in our study. The grey matter of patients with BPD was reduced in the hippocampus, but increased in the hypothalamus compared with healthy participants. Hypothalamic volume correlated positively with the history of traumatization in patients with BPD. No significant alterations were found in the amygdala and ACC. Limitations: This study is limited by the lack of measures of corticotropin-releasing hormone, adrenocorticotropic hormone and cortisol levels. Furthermore, moderate sample size and comorbid disorders need to be considered. Conclusion: Our findings provide new evidence for grey matter alterations in the hypothalamus and replicate previously reported decrements in hippocampal volume in patients with BPD. Understanding the role of the hypothalamus and other central stress-regulating structures could help us to further understand the neurobiological underpinnings of this complex disorder. ? 2013 Canadian Medical Association.
机译：背景：早期生活压力，增加的心理唤醒和身体的生理压力反应的经历似乎在边缘性人格障碍（BPD）的发病机理和维持中起着重要作用。在本研究中，我们调查了女性BPD患者中央应激调节结构的灰质变化。方法：我们使用全自动DARTEL基于体素的形态测量技术，对年龄，智力和教育相匹配的年龄，智力和教育水平相匹配的未药物治疗，右撇子BPD（根据DSM-IV标准）和健康对照的女性患者进行T1加权结构磁共振成像扫描。我们感兴趣的区域包括海马，杏仁核，前扣带回皮质（ACC）和下丘脑。结果：我们的研究招募了30名患者和33名对照。与健康受试者相比，BPD患者的灰质在海马区减少，但在下丘脑中增加。下丘脑容积与BPD患者的创伤史呈正相关。在杏仁核和ACC中未发现明显改变。局限性：本研究由于缺乏促肾上腺皮质激素释放激素，促肾上腺皮质激素和皮质醇水平的测定而受到限制。此外，需要考虑适度的样本量和合并症。结论：我们的发现为BPD患者下丘脑灰质改变提供了新证据，并复制了先前报道的海马体积减少的报道。了解下丘脑和其他中央压力调节结构的作用可以帮助我们进一步了解这种复杂疾病的神经生物学基础。 ？ 2013加拿大医学会。

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