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首页> 外文期刊>Journal of psychiatry & neuroscience: JPN >Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease.
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Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease.

机译：脑脊髓液中总tau和磷酸化tau 181蛋白水平与轻度认知障碍和阿尔茨海默病中脑萎缩的关系。

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BACKGROUND: We sought to examine the association of levels of total tau (t-tau) and phosphorylated tau 181 (p-tau181) protein with brain morphology in mild cognitive impairment, as defined by the concept of aging-associated cognitive decline (AACD) and Alzheimer disease. METHODS: Twenty-three participants with AACD, 16 with Alzheimer disease and 15 healthy controls underwent magnetic resonance imaging and lumbar puncture. We performed voxel-based morphometry to investigate the association between tau levels in cerebrospinal fluid (CSF) and cerebral grey matter density throughout the entire brain. RESULTS: Voxel-based morphometry revealed that both elevated t-tau and p-tau181 concentrations were associated with reduced grey matter density in temporal, parietal and frontal regions. Among participants with AACD, elevated levels of p-tau181 (but not t-tau) in CSF were correlated with a pronounced atrophy in the right hippocampus. LIMITATIONS: Our study was limited by the small sample, especially with respect to the analysis comprising the AACD subgroups. Moreover, we did not correct our voxel-based morphometry analyses for multiple dependent comparisons, therefore they harbour a risk of false-positive results. CONCLUSION: Elevated levels of t-tau and p-tau181 in CSF reflect degenerative processes in the cortical regions typically affected in Alzheimer disease. Our findings in participants with AACD support the hypothesis that p-tau181 might be more specifically related to neurodegenerative changes in early Alzheimer disease.
机译：背景：我们试图研究轻度认知障碍中总tau（t-tau）和磷酸化tau 181（p-tau181）蛋白水平与脑形态的关系，这是由衰老相关的认知功能减退（AACD）概念定义的和阿尔茨海默氏病。方法：23名AACD患者，16名阿尔茨海默氏病患者和15名健康对照者进行了磁共振成像和腰椎穿刺。我们进行了基于体素的形态测量，以研究脑脊液（CSF）中tau水平与整个大脑中脑灰质密度之间的关系。结果：基于体素的形态测定显示，t-tau和p-tau181浓度升高均与颞，顶和额叶区域灰质密度降低有关。在患有AACD的参与者中，脑脊液中p-tau181（而非t-tau）水平升高与右海马区明显萎缩相关。局限性：我们的研究受到小样本样本的限制，特别是在包含AACD亚组的分析方面。此外，我们没有针对多个相关的比较对基于体素的形态分析进行校正，因此它们存在产生假阳性结果的风险。结论：脑脊液中t-tau和p-tau181的水平升高反映了通常受阿尔茨海默病影响的皮质区域的退化过程。我们在AACD参与者中的发现支持以下假设：p-tau181可能与早期阿尔茨海默氏病的神经退行性改变更具体相关。

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