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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Reconstitution of thymic function in HIV-1 patients treated with highly active antiretroviral therapy.
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Reconstitution of thymic function in HIV-1 patients treated with highly active antiretroviral therapy.

机译：用高效抗逆转录病毒疗法治疗的HIV-1患者的胸腺功能重建。

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摘要

The extent to which highly active antiretroviral therapy can restore thymic function in HIV-1 infected patients is not known. We simulate treatment using a temporal model of thymopoiesis during HIV-1 infection, tracking thymic function by the number of recent thymic emigrants (RTE) exported to the periphery per day. Our results suggest that suppressing viral load in peripheral blood and improving inherent thymic function are necessary for the reconstitution of RTE levels in adult thymic infection with either R5 or X4 HIV-1 strains. This is also the case in pediatric thymic infection with R5 strains. However, recovery of RTE levels during pediatric infection with X4 strains also depends on high drug efficacy within the thymus. We further predict that protease inhibitors have high levels of efficacy directly suppressing viral replication within the thymus, while reverse transcriptase inhibitors have low efficacy.
机译：尚不知道在HIV-1感染的患者中高效抗逆转录病毒疗法可恢复胸腺功能的程度。我们使用HIV-1感染期间的胸腺生成的时间模型来模拟治疗，并通过每天输出到外围的最近胸腺移出物（RTE）的数量跟踪胸腺功能。我们的结果表明，抑制外周血中的病毒载量和改善固有的胸腺功能对于在R5或X4 HIV-1病毒株的成人胸腺感染中重建RTE水平是必要的。在小儿胸腺感染R5菌株时也是如此。但是，小儿X4株感染期间RTE水平的恢复还取决于胸腺内的高药效。我们进一步预测蛋白酶抑制剂具有直接抑制胸腺内病毒复制的高水平功效，而逆转录酶抑制剂具有低功效。

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