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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Transfer of alopecia areata in the human scalp graft/Prkdc(scid) (SCID) mouse system is characterized by a TH1 response.
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Transfer of alopecia areata in the human scalp graft/Prkdc(scid) (SCID) mouse system is characterized by a TH1 response.

机译：人头皮移植物/ Prkdc（scid）（SCID）小鼠系统中斑秃的转移以TH1反应为特征。

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摘要

Alopecia areata is an autoimmune condition directed at hair follicles, which results in loss of hair. We have previously demonstrated that it is possible to transfer hair loss, along with the immunohistologic findings of alopecia areata, to human scalp grafts on Prkdc(scid) (SCID) mice by injection of autologous activated lesional T-cells. This study examines the cytokine profile of T-cells and follicular epithelium following transfer of hair loss. Two consistent findings significantly (P < 0.01) associated with hair loss were production of interferon-gamma-inducible protein-10kDa (IP-10) by follicular epithelium (13/13), and production of INF-gamma by infiltrating T-cells (10/12). Noninjected control grafts regrew hair, and were generally negative for IP-10 (positive 2/9), and INF-gamma (positive 2/9), but expressed of IL-10 on the follicular epithelium (7/9). These data support an INF-gamma TH1 pathogenesis for hair loss in alopecia areata.
机译：斑秃是针对毛囊的自身免疫疾病，会导致脱发。我们以前已经证明，通过注射自体激活的病灶T细胞，可以将脱发以及斑秃的免疫组织学发现转移到Prkdc（scid）（SCID）小鼠的人头皮移植物中。这项研究检查了脱发转移后T细胞和卵泡上皮细胞因子的分布。与脱发相关的两个一致发现（P <0.01）是卵泡上皮细胞（13/13）产生的干扰素-γ诱导型蛋白10kDa（IP-10）和渗透T细胞产生的INF-γ（（ 10/12）。未注射的对照移植物使头发重新生长，通常IP-10（阳性2/9）和INF-γ（阳性2/9）阴性，但在滤泡上皮细胞中表达IL-10（7/9）。这些数据支持INF-γTH1发病机制用于斑秃的脱发。

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