首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Muscle-derived nitric oxide synthase expression, differences associated with muscle fiber-type, and disease susceptibility in a rat model of myasthenia gravis.
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Muscle-derived nitric oxide synthase expression, differences associated with muscle fiber-type, and disease susceptibility in a rat model of myasthenia gravis.

机译:在重症肌无力的大鼠模型中,肌肉来源的一氧化氮合酶表达,与肌肉纤维类型相关的差异以及疾病易感性。

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摘要

Reports from this laboratory suggested that expression of skeletal muscle-derived, inducible nitric oxide synthase (iNOS), is associated with resistance of a particular rat strain to the autoimmune model of myasthenia gravis (MG). The study reported below demonstrates a similar association between iNOS induction in skeletal muscle and disease-resistance when comparing different skeletal muscles originating from the same rat strain. Thus, soleus muscles, shown previously to be relatively resistant to disease even when obtained from disease-susceptible Lewis rats, were observed to express high levels of iNOS following exposure to antibody reactive with the nicotinic acetylcholine receptor (AChR). Increased iNOS expression appears to be associated with slow-twitch, type 1 fibers and would explain the relatively high iNOS expression in soleus muscles since they are dominated by this fiber type, compared to disease-susceptible EDL muscles which are dominated by fast-twitch, type 2 fibers.
机译:该实验室的报告表明,骨骼肌源性诱导型一氧化氮合酶(iNOS)的表达与特定大鼠品系对重症肌无力(MG)自身免疫模型的抗性有关。以下报道的研究表明,当比较源自同一大鼠品系的不同骨骼肌时,骨骼肌中iNOS的诱导与抗病性之间存在相似的关联。因此,观察到比目鱼肌,即使从易感疾病的Lewis大鼠身上获得的疾病,也比以前表现出对疾病的抵抗力,但在暴露于与烟碱乙酰胆碱受体(AChR)具有反应性的抗体后,其表达高水平的iNOS。 iNOS表达的增加似乎与慢肌1型纤维有关,并且可以解释比目鱼肌中iNOS的表达相对较高,因为与快易性为主的疾病易感性EDL肌肉相比,比目鱼肌主要由该纤维类型主导, 2型纤维。

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