首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient.
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Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient.

机译:肾移植患者原发性EBV感染期间EBV特异性CD4 +和CD8 + T细胞的详细动力学。

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摘要

The etiology of infectious mononucleosis is poorly understood and usually detected many weeks after infection. Here, we present a unique case of primary symptomatic EBV infection after kidney transplantation, in whom we analyzed both EBV-specific CD4+ and CD8+ T cells in detail from the moment of infection up to latency. We show that EBV-specific T-cell responses in peripheral blood during primary EBV infection after kidney transplantation peaked early after the appearance of viral load, but well before onset of IM symptoms, suggesting that IM in this case is not caused by high numbers of CD8+ T cells per se but may be caused by lack of homing to lymph nodes or tonsils.
机译:对传染性单核细胞增多症的病因了解甚少,通常在感染后数周即可检测到。在这里,我们介绍了肾脏移植后原发性症状性EBV感染的独特案例,在该案例中,我们从感染时刻到潜伏期详细分析了EBV特异性CD4 +和CD8 + T细胞。我们发现肾脏移植后原发性EBV感染期间外周血中EBV特异性T细胞反应在出现病毒负荷后,但在IM症状发作之前就达到峰值,这表明在这种情况下IM并非由大量的CD8 + T细胞本身,但可能是由于归巢于淋巴结或扁桃体缺乏所致。

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