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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Intrinsic ability of GM+IL-4 but not Flt3L-induced rat dendritic cells to promote allogeneic T cell hyporesponsiveness.
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Intrinsic ability of GM+IL-4 but not Flt3L-induced rat dendritic cells to promote allogeneic T cell hyporesponsiveness.

机译：GM + IL-4的内在能力，但不能促进Flt3L诱导的大鼠树突状细胞促进同种异体T细胞反应低下。

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摘要

The influence of GM+IL-4 and Flt3 ligand (FL) on phenotype and function of BM-derived DC from Lewis rats was investigated. GM+IL-4-induced DC, despite expression of CD80/CD86, were less stimulatory than FL-induced DC that expressed low CD80/CD86 and were efficient stimulators of allogeneic T cells. GM+IL-4 DC were CD11b+ OX62lo, whereas FL DC were CD11blo OX62+. Following activation, GM+IL-4 DC produced IL-10 and IL-6, but no IL-12p70, and were resistant to further maturation. FL DC produced IL-12p70, IFN-alpha/beta, IL-10 and IL-6 and underwent maturation. Repeated stimulation of T cells with GM+IL-4 DC inhibited proliferation, cytokine production and induced early T cell apoptosis. FL DC-activated T cells produced large amounts of IFN-gamma/IL-10 and exhibited late T cell apoptosisecrosis. In vivo, GM+IL-4 DC induced alloAg-specific hyporesponsiveness following T cell restimulation. These results demonstrate that GM+IL-4 DC display intrinsic regulatory properties, inducing passive-cell-death in T cells with potential for inactivation/regulation of alloreactive T cells in transplantation.
机译：研究了GM + IL-4和Flt3配体（FL）对Lewis大鼠BM衍生DC的表型和功能的影响。尽管表达CD80 / CD86，但GM + IL-4诱导的DC的刺激性低于表达CD80 / CD86的FL诱导的DC，并且是同种异体T细胞的有效刺激剂。 GM + IL-4 DC为CD11b + OX62lo，而FL DC为CD11blo OX62 +。激活后，GM + IL-4 DC产生IL-10和IL-6，但不产生IL-12p70，并且对进一步成熟具有抵抗力。 FL DC产生IL-12p70，IFN-α/β，IL-10和IL-6并进行成熟。 GM + IL-4 DC反复刺激T细胞抑制增殖，细胞因子产生并诱导早期T细胞凋亡。 FL DC激活的T细胞产生大量的IFN-γ/ IL-10，并表现出晚期T细胞凋亡/坏死。在体内，T细胞再刺激后，GM + IL-4 DC诱导了alloAg特异性低反应性。这些结果表明，GM + IL-4 DC具有内在的调节特性，可诱导T细胞中的被动细胞死亡，并具有潜在的失活/调节同种反应性T细胞的能力。

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