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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Costimulatory pathways mediate monocyte-dependent lymphocyte apoptosis in HIV.
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Costimulatory pathways mediate monocyte-dependent lymphocyte apoptosis in HIV.

机译：共刺激途径介导HIV中单核细胞依赖性淋巴细胞凋亡。

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摘要

Examination of annexin V binding, an indicator of early apoptosis, on lymphocytes from HIV+ people immediately after isolation showed that both CD4(+) and CD8(+) T cells were apoptotic, whereas B cell apoptosis was induced mainly after incubation. CD8(+) T cell apoptosis correlated with fewer CD4(+) T cells, but not the level of viremia. To determine potential mechanisms for apoptosis, we examined FasL expression, which was dramatically elevated on CD14(+) monocytes; however, antibody to FasL did not reproducibly inhibit apoptosis. Rather, CD8(+) T cell apoptosis was caused by antigen-presenting cells because removal of monocytes or addition of antibodies to CD80 and CD86 reduced apoptosis. B cell apoptosis also involved costimulatory signals delivered by T cells but not monocytes. A unique CD8(bright)CD28(dim) T cell population died after costimulation by monocytes. Because this population was increased in patients with undetectable viremia, abnormal antigen-presenting cells may contribute to continued CD8(+) T cell exhaustion by inducing apoptosis. Copyright 1999 Academic Press.
机译：分离后立即检查HIV +人淋巴细胞上膜联蛋白V的结合（早期凋亡的指标）表明CD4（+）和CD8（+）T细胞均凋亡，而B细胞凋亡主要是在孵育后诱导的。 CD8（+）T细胞凋亡与较少的CD4（+）T细胞相关，但与病毒血症水平无关。为了确定潜在的凋亡机制，我们检查了FasL表达，该表达在CD14（+）单核细胞上显着升高。但是，针对FasL的抗体不能可复制地抑制细胞凋亡。相反，CD8（+）T细胞凋亡是由抗原呈递细胞引起的，因为去除单核细胞或添加针对CD80和CD86的抗体可减少凋亡。 B细胞凋亡还涉及T细胞而非单核细胞传递的共刺激信号。单核细胞共刺激后，独特的CD8（亮）CD28（暗）T细胞群体死亡。因为在无法检测到病毒血症的患者中该人群增加了，所以异常的抗原呈递细胞可能通过诱导凋亡来促进CD8（+）T细胞的持续衰竭。版权所有1999，学术出版社。

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