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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?
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Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?

机译：1-磷酸鞘氨醇在肺结核病过程中是否起保护作用？

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摘要

Sphingosine 1-phosphate (S1P) has recently been reported to induce antimycobacterial activity in vitro and in a mouse model of in vivo Mycobacterium tuberculosis infection. However, its role in the course of pulmonary tuberculosis in humans is still not known. This study shows that S1P levels in airway surface fluid of tuberculosis (TB) patients are significantly less than those observed in non-TB control patients. Moreover, the in vitro stimulation of bronchoalveolar lavage cells coming from TB patients with S1P significantly reduces intracellular growth of endogenous mycobacterial isolates. These results show that, in the course of pulmonary TB, airway epithelial fluid-associated S1P may play a protective role in the containment of intracellular mycobacterial growth and that its decrease may represent a novel pathogenic mechanism through which M. tuberculosis favors its replication.
机译：最近有报道说1-磷酸鞘氨醇（S1P）在体外和在体内结核分枝杆菌感染的小鼠模型中诱导抗分枝杆菌活性。然而，其在人类肺结核病过程中的作用仍然未知。这项研究表明，结核病（TB）患者气道表面液中的S1P水平显着低于非结核病对照患者中观察到的S1P水平。此外，用S1P对来自结核病患者的支气管肺泡灌洗细胞进行体外刺激显着降低了内源分枝杆菌分离株的细胞内生长。这些结果表明，在肺结核病过程中，气道上皮液相关的S1P可能在细胞内分枝杆菌生长的抑制中起保护作用，并且其减少可能代表结核分枝杆菌通过其促进其复制的新的致病机制。

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