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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Role of anti-nucleosome antibody in the diagnosis of systemic lupus erythematosus.
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Role of anti-nucleosome antibody in the diagnosis of systemic lupus erythematosus.

机译：抗核小体抗体在系统性红斑狼疮诊断中的作用。

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OBJECTIVE: To investigate the role of anti-nucleosome antibodies (AnuA) in systemic lupus erythematosus (SLE). METHODS: IgG anti-nucleosome antibodies were detected by enzyme-linked immunosorbent assay (ELISA) in the sera of 233 SLE and 220 other rheumatic diseases' patients as well as 31 health controls. The patients were also evaluated for clinical and biological parameters. RESULTS: (1) Out of 233 SLE patients, 144 (61.8%) were seropositive for AnuA, which was significantly higher than that of patients with other rheumatic diseases [2.7% (6/220), P < 0.001]; the sensitivities and specificities of AnuA in SLE were 61.8% and 97.6%, respectively. (2) The positive rated of AnuA in SLE lacking of anti-DNP, anti-cmDNA, anti-Sm and anti-dsDNA antibodies were 57.1%, 55.9%, 62.4% and 51.2%, respectively. (3) The frequency of the fever, skin rash, and arthralgia were significantly higher in 144 positive AnuA SLE than those in AnuA negative SLE (P < 0.05). The frequency of leukopenia, elevations of ESR and CRP, lower C3/C4 levels and proteinuria in AnuA positive groups was significantly higher than that of AnuA negative groups (P < 0.05). (4) Level of AnuA was strongly correlated with the SLEDAI scores (r = 0.385, P < 0.001). Patients with active SLE showed significantly higher positive rate of AnuA (66.1%) than those with inactive disease (45.7%) (chi2 = 6.568, P = 0.010). CONCLUSIONS: AnuA is one of the most valuable markers in the diagnosis of SLE lacking of anti-dsDNA, anti-Sm, anti-DNP and anti-cmDNA antibodies. The level of AnuA is associated with the disease activity of SLE.
机译：目的：探讨抗核小体抗体（AnuA）在系统性红斑狼疮（SLE）中的作用。方法：采用酶联免疫吸附法（ELISA）检测了233例SLE和220名其他风湿病患者以及31名健康对照者血清中的IgG抗核小体抗体。还评估了患者的临床和生物学参数。结果：（1）在233例SLE患者中，有144例（61.8％）对AnuA呈血清反应阳性，这明显高于其他风湿病患者[2.7％（6/220），P <0.001]; SLE中AnuA的敏感性和特异性分别为61.8％和97.6％。 （2）缺乏抗DNP，抗cmDNA，抗Sm和抗dsDNA抗体的SLE中AnuA的阳性评分分别为57.1％，55.9％，62.4％和51.2％。 （3）144例阳性AnuA SLE的发烧，皮疹和关节痛的频率显着高于AnuA阴性SLE（P <0.05）。 AnuA阳性组白细胞减少症的频率，ESR和CRP升高，C3 / C4水平降低和蛋白尿明显高于AnuA阴性组（P <0.05）。 （4）AnuA水平与SLEDAI评分高度相关（r = 0.385，P <0.001）。活动性SLE患者的AnuA阳性率（66.1％）显着高于非活动性疾病（45.7％）（chi2 = 6.568，P = 0.010）。结论：AnuA是SLE缺乏抗dsDNA，抗Sm，抗DNP和抗cmDNA抗体的最有价值的标志物之一。 AnuA的水平与SLE的疾病活动性相关。

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