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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Association of IL-10 and TNFalpha genotypes with ANCA appearance in ulcerative colitis.
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Association of IL-10 and TNFalpha genotypes with ANCA appearance in ulcerative colitis.

机译：溃疡性结肠炎中IL-10和TNFalpha基因型与ANCA出现的相关性。

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摘要

The appearance of autoantibodies is a common characteristic of ulcerative colitis (UC). Specifically, anti-neutrophil cytoplasmic antibodies (ANCA) are the most prevalent in this disease and their synthesis may be genetically conditioned. The aim of the present study was to test the influence on appearance of autoantibodies of IL-10 and TNFalpha genes promoter polymorphisms, which control cytokine levels. Genetic polymorphisms of TNFalpha (-308 G/A) and IL-10 (-1082 G/A) and ANCA and anti-goblet cells antibodies (GAB) presence were determined in 99 UC patients. The -308A* allele and -308AA/AGTNFalpha genotypes (high producer), clearly correlated with ANCA positivity (p = 0.004 and p = 0.007, respectively). Additionally, homozygous carriage of the -1082A*IL-10 allele (low producer) significantly associated with ANCA presence (p = 0.007). Furthermore, combination of both genotypes (low IL-10/high TNFalpha producer genotype) had a greater influence on ANCA positivity than each individual genotype (p = 0.008). ANCA production in UC thus appears to be conditioned by IL-10 and TNFalpha genotypes.
机译：自身抗体的出现是溃疡性结肠炎（UC）的共同特征。具体而言，抗中性粒细胞胞质抗体（ANCA）在该疾病中最普遍，其合成可能经过遗传调控。本研究的目的是测试对控制细胞因子水平的IL-10和TNFalpha基因启动子多态性对自身抗体外观的影响。在99例UC患者中确定了TNFalpha（-308 G / A）和IL-10（-1082 G / A）的遗传多态性以及ANCA和抗杯状细胞抗体（GAB）的存在。 -308A *等位基因和-308AA / AGTNFalpha基因型（高产），与ANCA阳性明显相关（分别为p = 0.004和p = 0.007）。此外，-1082A * IL-10等位基因（低生产者）的纯合携带与ANCA的存在显着相关（p = 0.007）。此外，两种基因型的组合（低IL-10 /高TNFα生产者基因型）对ANCA阳性的影响要大于每种基因型（p = 0.008）。因此，UC中ANCA的产生似乎受到IL-10和TNFalpha基因型的调节。

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