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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The CD40/CD40 ligand system is involved in the pathogenesis of pemphigus.
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The CD40/CD40 ligand system is involved in the pathogenesis of pemphigus.

机译：CD40 / CD40配体系统与天疱疮的发病有关。

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摘要

The CD40/CD40 ligand (CD40L) system has never been investigated in autoimmune bullous diseases belonging to the pemphigus group in humans. Skin biopsy specimens from 21 patients with pemphigus vulgaris, 10 with pemphigus foliaceous and healthy volunteers were studied by immunohistochemistry (for CD40 and CD40L) and reversal transcriptase polymerase-chain reaction (for CD40L), while sera were analyzed by enzyme-linked immunosorbent assay for soluble CD40L. In all pemphigus specimens, the basal and suprabasal layers of the epidermis and perivascular infiltrating cells were CD40+. CD40L+ cells moderately infiltrated the perivascular and interstitial dermis of pemphigus specimens. CD40L mRNA was strongly evident in all pemphigus samples while no signal was detected in the healthy controls. The expression of soluble CD40L was significantly greater in pemphigus sera than in controls. We showed here that the CD40/CD40L system is upregulated both in lesional skin and in serum of patients with pemphigus.
机译：从未在属于人类天疱疮组的自身免疫性大疱性疾病中研究CD40 / CD40配体（CD40L）系统。通过免疫组织化学（针对CD40和CD40L）和逆转录酶聚合酶链反应（针对CD40L）研究了21例寻常型天疱疮患者，10例叶天疱疮和健康志愿者的皮肤活检标本，同时通过酶联免疫吸附法分析了血清可溶性CD40L。在所有天疱疮标本中，表皮的基底层和基底上层以及血管周围浸润细胞均为CD40 +。 CD40L +细胞适度浸润天疱疮标本的血管周围和间质真皮。 CD40L mRNA在所有天疱疮样本中都非常明显，而在健康对照中未检测到信号。天疱疮血清中可溶性CD40L的表达明显高于对照组。我们在这里显示，天疱疮患者的病变皮肤和血清中的CD40 / CD40L系统均被上调。

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