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A protective role for innate immunity in autoimmune disease.

机译:先天免疫在自身免疫性疾病中的保护作用。

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摘要

Systemic lupus erythematosus is an incurable autoimmune disease characterized by autoantibodies directed against highly conserved nuclear proteins and DNA. While the cause of lupus is not known, B-lymphocytes are essential for disease. Most striking is that deficiency in components of the innate immune system such as complement is a major risk factor in disease. One explanation for the involvement of complement and innate immunity is that they are important in the induction and maintenance of B cell tolerance to lupus antigens. Copyright 2000 Academic Press.
机译:系统性红斑狼疮是一种无法治愈的自身免疫性疾病,其特征是针对高度保守的核蛋白和DNA的自身抗体。虽然不知道狼疮的病因,但B淋巴细胞对于疾病至关重要。最令人吃惊的是,先天免疫系统的组成成分(例如补体)缺乏是疾病的主要危险因素。补体和先天免疫参与的一种解释是它们在诱导和维持B细胞对狼疮抗原的耐受性中很重要。版权所有2000学术出版社。

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