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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Humoral and cell-mediated immunity in mice with genetic deficiencies of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormone.
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Humoral and cell-mediated immunity in mice with genetic deficiencies of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormone.

机译：具有催乳素，生长激素，胰岛素样生长因子-I和甲状腺激素等遗传缺陷的小鼠的体液和细胞介导的免疫。

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摘要

Prolactin (PRL), growth hormone (GH), insulin-like growth factor-I (IGF-I), and thyroid hormones have been proposed as critical immunoregulatory mediators, and their clinical use is being considered. The precise role played by each of these hormones in the generation of humoral and cell-mediated immune responses was assessed in a panel of mice with mutations that result in a selective reduction of PRL, GH, IGF-I, and/or thyroid hormone production. A surprising result, in view of previous studies indicating an immunoregulatory role for these hormones, was that all mice generated normal humoral and cell-mediated immune responses following challenge with T-independent and T-dependent antigens and with Listeria monocytogenes. A review of these findings in the context of previous data has resulted in the formulation of a working hypothesis proposing that these hormones act as anabolic and/or stress modulating mediators with effects on most cells, including those of the immune system. When considered in this context, it is possible to reconcile the contradictory data. Copyright 2000 Academic Press.
机译：催乳素（PRL），生长激素（GH），胰岛素样生长因子-I（IGF-1）和甲状腺激素已被提议作为关键的免疫调节介质，并且正在考虑其临床应用。在一组突变导致选择性降低PRL，GH，IGF-I和/或甲状腺激素产生的突变小鼠中，评估了每种激素在体液和细胞介导的免疫反应产生中的确切作用。 。鉴于先前的研究表明这些激素具有免疫调节作用，因此令人惊讶的结果是，在用T依赖性和T依赖性抗原以及单核细胞增生性李斯特菌攻击后，所有小鼠均产生正常的体液和细胞介导的免疫反应。在先前数据的背景下对这些发现的综述导致提出了有效的假设，表明这些激素充当合成代谢和/或压力调节介体，对大多数细胞（包括免疫系统的细胞）产生影响。在这种情况下考虑时，可以调和矛盾的数据。版权所有2000学术出版社。

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