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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Prion diseases and the immune system.
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Prion diseases and the immune system.

机译：on病毒疾病和免疫系统。

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摘要

Transmissible spongiform encephalopathies are caused by unusual infectious agents that are purported to contain a single type of macromolecule, a modified host glycoprotein. The term prion has been applied to this group of agents. Surprisingly, the immune system appears to behave as a Trojan's horse rather than a protective fortification during prion infections. Because prions seem to be essentially composed of a protein, PrP(Sc), identical in sequence to a host encoded protein, PrP(C), the specific immune system displays a natural tolerance. However, lymphoid organs are strongly implicated in the preclinical stages of the disease. Certain immunodeficient animals are resistant to prions after peripheral inoculation. In normal subjects, cells of the immune system support the replication of prions and/or allow neuroinvasion. A better understanding of these aspects of prion diseases could lead to immunomanipulation strategies aimed at preventing the spread of infectious agents to the central nervous system. Copyright 2000 Academic Press.
机译：传染性海绵状脑病是由不寻常的传染原引起的，这些传染原据称包含单一类型的大分子，即修饰的宿主糖蛋白。 ion病毒一词已应用于这组代理。出人意料的是，在infection病毒感染期间，免疫系统表现得像特洛伊木马，而不是保护性防御工事。由于病毒似乎基本上由蛋白质PrP（Sc）组成，其蛋白序列与宿主编码的蛋白质PrP（C）相同，因此特异性免疫系统显示出天然的耐受性。但是，淋巴器官与疾病的临床前阶段密切相关。某些免疫缺陷动物在外周接种后对病毒具有抗性。在正常受试者中，免疫系统的细胞支持of病毒的复制和/或允许神经入侵。对病毒疾病的这些方面的更好理解可能会导致旨在防止传染原扩散到中枢神经系统的免疫操纵策略。版权所有2000学术出版社。

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