• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II.
【24h】

Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II.

机译：花生过敏受试者及其花生耐受性兄弟姐妹的花生特异性IgG差异很大，而与HLA II类无关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We enrolled 53 peanut-allergic subjects and 64 peanut-tolerant full siblings, measured peanut-specific IgG and IgE, determined HLA class II at high resolution, and analyzed DRB1 alleles by supertypes. Peanut-specific IgG and IgE were elevated in the peanut-allergic subjects (p<0.0001) but did not stratify with HLA alleles, haplotypes, or supertypes. There were no significant differences in HLA class II between the peanut-allergic and peanut-tolerant siblings but there was an increased frequency of DRB1*0803 in both sets of siblings compared to unrelated controls (p(c)=4.5x10). Furthermore, we identified 14 sibling pairs in which the peanut-allergic and the peanut-tolerant siblings have identical HLA class II and again found an elevation of anti-peanut IgG in the peanut-allergic subjects (p<0.0001). In conclusion, although DRB1*0803 may identify a subset of families with increased risk of peanut allergy, differences in peanut-specific immunoglobulin production between peanut-allergic subjects and their peanut-tolerant siblings are independent of HLA class II.
机译：我们招募了53位花生过敏受试者和64位花生耐受全兄弟姐妹，测量了花生特异性IgG和IgE，以高分辨率测定了HLA II类，并通过超型分析了DRB1等位基因。花生过敏受试者中花生特异性IgG和IgE升高（p <0.0001），但未与HLA等位基因，单倍型或超型分层。花生过敏和耐花生的兄弟姐妹之间的HLA II类没有显着差异，但与不相关的对照组相比，两组兄弟姐妹中DRB1 * 0803的频率都有增加（p（c）= 4.5x10）。此外，我们鉴定了14对兄弟姐妹，其中对花生过敏和对花生耐受的兄弟姐妹具有相同的HLA II类，并再次在对花生过敏的受试者中发现了抗花生IgG升高（p <0.0001）。总之，尽管DRB1 * 0803可能识别出花生过敏风险增加的家庭子集，但花生过敏受试者与其耐花生兄弟姐妹之间花生特异性免疫球蛋白产生的差异与HLA II类无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号