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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Live Attenuated Influenza Virus (LAIV) induces different mucosal T cell function in nonsmokers and smokers
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Live Attenuated Influenza Virus (LAIV) induces different mucosal T cell function in nonsmokers and smokers

机译：减毒活病毒（LAIV）在非吸烟者和吸烟者中诱导不同的粘膜T细胞功能

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摘要

Smokers are more susceptible to respiratory infections, including influenza. To explore the effect of smoking on influenza-induced responses within the nasal mucosa, we have developed a protocol using inoculation with live attenuated influenza virus (LAIV) vaccine followed by sampling of the nasal mucosa. Mucosal cell populations were harvested through superficial biopsy of the nasal inferior turbinate pre and post LAIV inoculation and analyzed using flow cytometry. The majority of nasal biopsy CD45. + immune cells at baseline were CD3. + T lymphocytes. Following LAIV, these lymphocytes increased in nonsmokers but not in smokers. A subset of individuals was negative for helper T cell marker CD4 and cytotoxic T cell marker CD8 but positive for the γδ T cell receptor (TCR). Increases in γδ TCR. + cells were greater in nonsmokers, than in smokers. Thus, LAIV-induced changes in CD3 T as well as γδ T lymphocyte percentages are suppressed in smokers compared to nonsmokers.
机译：吸烟者更容易感染呼吸道感染，包括流感。为了探索吸烟对鼻粘膜内流感诱导反应的影响，我们开发了一种方案，该方法使用活减毒流感病毒（LAIV）疫苗接种，然后对鼻粘膜取样。 LAIV接种前后，通过鼻下鼻甲的浅表活检收集粘膜细胞群，并使用流式细胞仪进行分析。鼻腔活检多数为CD45。基线时+免疫细胞为CD3。 + T淋巴细胞。 LAIV后，这些不吸烟者的淋巴细胞增多，而吸烟者则没有。一部分个体对辅助T细胞标记CD4和细胞毒性T细胞标记CD8阴性，但对γδT细胞受体（TCR）阳性。 γδTCR增加。非吸烟者中的+细胞数量大于吸烟者。因此，与非吸烟者相比，LAIV诱导的吸烟者CD3 T和γδT淋巴细胞百分比的变化被抑制。

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