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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Can dendritic cells still be tamed in systemic lupus erythematosus?
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Can dendritic cells still be tamed in systemic lupus erythematosus?

机译：树突状细胞是否仍可以被系统性红斑狼疮所驯服？

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摘要

Dendritic cells (DC) are professional antigen-presenting cells (APC) which have the unique ability to induce and sustain immune responses. DC constitute a complex and plastic system of cells, which comprise several subsets that are at different stages of maturation. Immature, antigen-capturing DC in peripheral tissues sense pathogens, tissue necrosis, and local inflammation. These "danger" signals induce DC to undergo a maturation process while migrating into T cell areas of draining lymph nodes. There, they present processed antigens to T cells resulting in T cell proliferation and activation [1]. There is now evidence that immature DC during steady state conditions capture self-antigens and present them to T cells that lead to inactivate potentially self-reactive T cells (anergy) and/or to promote the development of regulatory T cells [2]. This process has been shown as a key event of the so called peripheral tolerance. In contrast, if antigen-loaded DC undergo maturation, they induce antigen-specific immunity [3]. Thus unabated DC activation may skew self-antigen presentation from tolerance to autoimmunity [4].
机译：树突状细胞（DC）是专业的抗原呈递细胞（APC），具有诱导和维持免疫反应的独特能力。 DC构成了一个复杂而可塑性的细胞系统，其中包括处于不同成熟阶段的几个子集。外周组织中未成熟的捕获抗原的DC会感应病原体，组织坏死和局部炎症。这些“危险”信号诱导DC迁移到引流淋巴结的T细胞区域时经历成熟过程。在那里，他们将加工过的抗原呈递给T细胞，导致T细胞增殖和活化[1]。现在有证据表明，在稳定状态下未成熟的DC会捕获自身抗原并将其呈递给T细胞，从而导致潜在的自我反应性T细胞（无能）失活和/或促进调节性T细胞的发育[2]。该过程已显示为所谓的外围公差的关键事件。相反，如果负载抗原的DC成熟，它们会诱导抗原特异性免疫[3]。因此，未减弱的DC激活可能会使自身抗原的表现从对自身免疫的耐受性倾斜[4]。

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