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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Immune function in patients with rheumatoid arthritis treated with etanercept.
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Immune function in patients with rheumatoid arthritis treated with etanercept.

机译：依那西普治疗类风湿关节炎患者的免疫功能。

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摘要

Etanercept, a recombinant human tumor necrosis factor (TNF) inhibitor that binds both soluble and cell-bound TNF, has been shown to reduce disease activity and inhibit joint destruction when administered to patients with rheumatoid arthritis (RA). Because TNF receptors are found on many types of cells that modulate the immune response, we evaluated the general immune function of a subset of RA patients in a blinded clinical study. No significant differences were seen between patients treated with etanercept or placebo in the surface antigen phenotypes of peripheral blood leukocytes, T cell proliferative responses, neutrophil function, delayed-type hypersensitivity (DTH) reactions, serum immunoglobulin levels, or incidence of infections. Although this observational study was relatively small and could detect only major changes in immunological status, the stability of immune function over time in patients receiving etanercept corroborates the findings in clinical studies, which suggest that etanercept does not alter overall global immune function.
机译：Etanercept是一种重组人肿瘤坏死因子（TNF）抑制剂，与可溶性和细胞结合的TNF结合，已显示对风湿性关节炎（RA）的患者可降低疾病活性并抑制关节破坏。由于在调节免疫应答的多种类型的细胞上都发现了TNF受体，因此我们在一项盲目的临床研究中评估了一部分RA患者的总体免疫功能。在接受依那西普或安慰剂治疗的患者之间，外周血白细胞的表面抗原表型，T细胞增殖反应，中性粒细胞功能，迟发型超敏反应（DTH）反应，血清免疫球蛋白水平或感染发生率无显着差异。尽管这项观察性研究规模相对较小，并且只能检测到免疫状态的重大变化，但接受依那西普的患者随着时间的推移免疫功能的稳定性证实了临床研究的结果，这表明依那西普不会改变整体的整体免疫功能。

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