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首页> 外文期刊>Journal of receptor and signal transduction research >G protein-coupled receptor oligomerization for what
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G protein-coupled receptor oligomerization for what

机译：G蛋白偶联受体的寡聚作用是什么

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摘要

Although the G protein-coupled receptor (GPCR) oligomerization has been questioned during the last decade, under some premises the existence of a supramolecular organization of these receptors begins now to be widely accepted by the scientific community. Indeed, GPCR oligomers may enhance the diversity and performance by which extracellular signals are transferred to the G proteins in the process of receptor transduction, although the mechanism that underlie this phenomenon remains still unexplained. Recently, a trans-conformational switching model has been proposed as a mechanism allowing direct inhibition of receptor activation. Thus, heterotropic receptorreceptor allosteric regulations are behind the GPCR oligomeric function. Accordingly, we revise here how GPCR oligomerization impinge in several important receptor functions like biosynthesis, plasma membrane diffusion or velocity, pharmacology and signaling. Overall, the rationale of receptor oligomerization might lie in the cellular need of sensing complex extracellular signals and to translate into a simple computational mode.
机译：尽管在过去的十年中对G蛋白偶联受体（GPCR）的寡聚化提出了质疑，但在某些前提下，这些受体的超分子组织形式已开始为科学界所广泛接受。确实，GPCR低聚物可以增强在受体转导过程中将细胞外信号转移至G蛋白的多样性和性能，尽管仍无法解释造成这种现象的机制。近来，已经提出了跨构象转换模型作为允许直接抑制受体激活的机制。因此，异质性受体的变构调控是GPCR寡聚功能的背后。因此，我们在这里修改GPCR寡聚化如何影响几种重要的受体功能，例如生物合成，质膜扩散或速度，药理学和信号传导。总体而言，受体低聚的基本原理可能在于细胞需要检测复杂的细胞外信号并将其转化为简单的计算模式。

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