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首页> 外文期刊>Journal of receptor and signal transduction research >Yin Yang-1(YY-1) expression in idiopathic pulmonary fibrosis
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Yin Yang-1(YY-1) expression in idiopathic pulmonary fibrosis

机译：阴阳1（YY-1）在特发性肺纤维化中的表达

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Context: Yin Yang-1 (YY-1) is implicated in the pathogenesis of lung cancer which can be complicated with idiopathic pulmonary fibrosis (IPF). Objective: The aim of the study was to investigate whether YY-1 is involved in the pathogenesis of IPF and whether represents a common pathogenetic pathway which could explain the coexistence of these disorders. Materials and methods: Lung tissue from 52 patients (37 with IPF and 15 controls) and bronchoalveolar lavage fluid (BALF) from 34 patients (25 with IPF and 9 controls) were studied and YY-1 mRNA expression was evaluated by real-time PCR. Results: YY-1 was expressed in 8% (3/37) of IPF patients and in 6% (1/15) of healthy controls in tissue samples. In addition, 12% (3/25) of IPF patients and 33% (3/9) of healthy controls have expressed YY-1 gene in BALF samples. However, no statistical significant difference in mRNA expression between patients and controls has been detected in both tissue and BAL fluid samples. Discussion and conclusion: Our results do not support the hypothesis of YY-1 involvement in IPF. However, similar expression of YY-1 gene in two biological samples cannot exclude a possible role of this polymorphic gene in the pathway of IPF. Further studies in a larger scale of patients are needed.
机译：背景：阴阳1号（YY-1）与肺癌的发病机制有关，其可能并发特发性肺纤维化（IPF）。目的：该研究的目的是调查YY-1是否参与IPF的发病机制，以及是否代表可以解释这些疾病共存的常见致病途径。材料和方法：研究了52例患者（37例IPF和15例对照）的肺组织和34例患者（25例IPF和9例对照）的支气管肺泡灌洗液（BALF），并通过实时PCR评估了YY-1 mRNA表达。结果：YY-1在IPF患者的8％（3/37）和组织样本的6％（1/15）的健康对照中表达。此外，在BALF样本中有12％（3/25）的IPF患者和33％（3/9）的健康对照表达了YY-1基因。但是，在组织和BAL液体样本中，患者和对照之间在mRNA表达上均未发现统计学显着差异。讨论与结论：我们的结果不支持YY-1参与IPF的假设。但是，YY-1基因在两个生物学样品中的相似表达不能排除该多态基因在IPF途径中的可能作用。需要在更大范围的患者中进行进一步研究。

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