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首页> 外文期刊>Journal of Reproductive Immunology >Macrophages and not granulocytes are involved in cervical ripening.
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Macrophages and not granulocytes are involved in cervical ripening.

机译：巨噬细胞而不是粒细胞参与宫颈成熟。

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To clarify the role of leucocytes in human cervical ripening and dilatation, cervical biopsies were obtained from six non-pregnant women, eight women undergoing early termination of pregnancy, 18 pregnant women undergoing elective Caesarean section at term (both with and without a ripe cervix as determined by Bishop score) and 11 women after term vaginal delivery. Leucocytes were localised by immunohistochemistry labelling and quantified in subepithelial and deep stromal areas. CD45+ leucocytes were more numerous in the subepithelial area of the cervix than in the deep stroma in all groups (P<0.01). CD14+ macrophages and CD15+ granulocytes were increased in both the subepithelial and deep stromal areas only in the vaginal delivery group (P<0.01). The number of macrophages in the ripening cervix (Bishop score above 4) was higher than in the unripe cervix (Bishop score 4 or less; P<0.05) with no differences in other leucocyte populations. CD3+ CD8+ T cells in the subepithelial area were reduced in late pregnancy and after vaginal delivery (P<0.01), but showed no relationship to Bishop score. Macrophages and granulocytes may be involved in the process of cervical dilatation, but macrophage infiltration into the ripening cervix before labour suggests their role in the ripening process. Reduced numbers of CD3+ CD8+ T-lymphocytes in late pregnancy and after vaginal delivery suggests that local immunity is down-regulated in the late pregnancy period. Regional differences in leucocyte subpopulations in the cervix indicate that leucocyte infiltration is likely to be regulated by local factors.
机译：为了阐明白细胞在人宫颈成熟和扩张中的作用，从六名未怀孕的妇女，八名正在接受早期终止妊娠的妇女，十八名在足月进行选择性剖宫产的孕妇（分别有或没有成熟的子宫颈）进行了宫颈活检。由Bishop评分确定）和足月分娩后的11名妇女。通过免疫组织化学标记定位白细胞，并在上皮下和深层基质区域定量。在所有子宫颈中，子宫颈上皮下区域的CD45 +白细胞数量均多于深层间质（P <0.01）。仅在阴道分娩组中，上皮下和深层基质区域的CD14 +巨噬细胞和CD15 +粒细胞均增加（P <0.01）。子宫颈成熟（Bishop得分高于4）的巨噬细胞数量高于未成熟子宫颈（Bishop得分4或更低; P <0.05），其他白细胞群体无差异。妊娠后期和阴道分娩后上皮下区域的CD3 + CD8 + T细胞减少（P <0.01），但与Bishop评分无关。巨噬细胞和粒细胞可能参与了宫颈扩张的过程，但是在分娩前巨噬细胞浸入成熟子宫颈表明了它们在成熟过程中的作用。妊娠晚期和阴道分娩后CD3 + CD8 + T淋巴细胞数量减少，表明局部免疫在妊娠晚期被下调。子宫颈中白细胞亚群的区域差异表明白细胞浸润可能受局部因素调节。

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